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NCT03692416
The Effect of Some Drugs Used in Treatment of Vasculitis on the Complement System in Children
Phase 3 trial testing Ibuprofen in Vasculitis in 70 participants. Status unknown.
11 November 2021
Quick facts
| Lead sponsor | Assiut University |
|---|---|
| Phase | Phase 3 |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 70 |
| Start date | 11 November 2018 |
| Primary completion | 11 November 2021 |
| Estimated completion | 11 May 2022 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Ibuprofen (ibuprofen) — full drug profile →
- Prednisone (prednisone) — full drug profile →
- Methotrexate — full drug profile →
Conditions studied
- Vasculitis — all drugs for Vasculitis →
Sponsor
Assiut University
Who can join
Adults 1 Month to 17, any sex, with Vasculitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Vasculitis denotes affection of small to medium sized vessels by polyangitis. Antineutrophil cytoplasmic antibodies (ANCA) are immunoglobulin G (IgG) autoantibodies directed against constituents of neutrophil granules leading to neutrophil degeneration which results in cell apoptosis known as "Natoptosis" (NaTosis) of the cells. These lead to vessel endothelial cell damage. So that, ANCA formation seems to be the basic reaction in vasculitis. Complement activation at C3 and C4 was thought to be involved in renal damage ANCA associated vasculitis (AAV).
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT03692416
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03692416 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Assiut University
- Last refreshed: 15 February 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03692416.
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