NCT03690999 (RAMP) is a NA clinical trial of Prebiotic supplement in Microbiome, sponsored by Stanford University.

Who is sponsoring NCT03690999?

NCT03690999 is sponsored by Stanford University.

What drugs are being tested in NCT03690999?

Interventions in NCT03690999: Placebo, Prebiotic supplement.

What condition does NCT03690999 study?

NCT03690999 studies Microbiome, Immune Function, Inflammation.

Is NCT03690999 still recruiting?

NCT03690999 is currently completed. Last updated 17 February 2023.

Last reviewed 2023-02-17 · How we verify

NCT03690999: RAMP

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The RAMP Study - Rejuvenation of the Aging Microbiota With Prebiotics

Completed NA Last updated 17 February 2023

What this trial tests

NA trial testing Placebo in Microbiome in 98 participants. Completed in 14 December 2020.

Timeline

14 March 2019

Primary endpoint
13 November 2020

14 December 2020

Quick facts

Lead sponsor	Stanford University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	prevention
Enrollment	98
Start date	14 March 2019
Primary completion	13 November 2020
Estimated completion	14 December 2020
Sites	1 location across United States

Drugs / interventions tested

Placebo
Prebiotic supplement

Conditions studied

Microbiome — all drugs for Microbiome →
Immune Function — all drugs for Immune Function →
Inflammation — all drugs for Inflammation →

Sponsor

Stanford University

Who can join

60 and older, any sex, with Microbiome or Immune Function. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

An individual's immune and metabolic status is coupled to consumed carbohydrates. Complex carbohydrates that are not digested by human enzymes may influence host biology by impacting microbiota composition and function, or act in a yet-unknown microbiota-independent manner. Prebiotics offer a promising safe route to influence host health, possibly via the microbiota. However, it remains largely unknown to what extent immune function and metabolism can be modulated by prebiotics.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Gut dysbiosis and age-related neurological diseases; an innovative approach for therapeutic interventions.
Holmes A, Finger C, Morales-Scheihing D, Lee J, et al · · 2020 · cited 43× · PMID 32755639 · DOI 10.1016/j.trsl.2020.07.012
A human milk oligosaccharide alters the microbiome, circulating hormones, and metabolites in a randomized controlled trial of older adults.
Carter MM, Demis D, Perelman D, St Onge M, et al · · 2025 · cited 8× · PMID 40738103 · DOI 10.1016/j.xcrm.2025.102256

Verify or expand the search:

Other trials of Prebiotic supplement

Trials testing the same drug.

NCT05212545 — Effects of Prebiotics on Intestinal Colonization and Mood in a University Cohort · NA · completed
NCT04798417 — Nutrition to Relieve IBS Constipation · NA · completed

Other recruiting trials for Microbiome

Currently open trials in the same condition.

NCT07501455 — Comparison of the Effects of Oral Hygiene Regimens on Clinical, Immunomodulatory, and Microbial Outcomes and Oral Tolera · NA · recruiting
NCT07439718 — The Effects of an Oral Nutritional Intervention on the Small Intestine Microbiome · NA · recruiting
NCT07209007 — Dynamics of Dysbiosis in the Skin and Gut Microbiome of Burn Patients · recruiting
NCT06778083 — STI Prophylaxis and Emergence of Antimicrobial Resistance · recruiting
NCT06606119 — The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma · recruiting

Other Stanford University trials

Trials by the same sponsor.

NCT05945147 — Ketamine and Midazolam Infusions for CRPS: Feasibility Study · Phase 2 · withdrawn
NCT04225949 — Patients Understanding of PROM Graphs · NA · withdrawn
NCT06273098 — School-Based Bladder Health Intervention · NA · withdrawn
NCT04652635 — Management of Nailbed Injuries · NA · withdrawn
NCT05443503 — Stanford Spine Keeper - Managing Your Low Back Pain · NA · suspended

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03690999 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Stanford University
Last refreshed: 17 February 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03690999.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing