NCT03689491: rTMS

The Combining rTMS With Visual Feedback Training for Patients With Stroke

Completed NA Last updated 18 January 2023

What this trial tests

NA trial testing rTMS in Stroke in 30 participants. Completed in 31 July 2019.

Timeline

5 January 2017

Primary endpoint
30 June 2019

31 July 2019

Quick facts

Lead sponsor	Taipei Medical University Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	30
Start date	5 January 2017
Primary completion	30 June 2019
Estimated completion	31 July 2019
Sites	1 location across Taiwan

Drugs / interventions tested

• rTMS
• visual feedback training
• traditional rehabilitation

Conditions studied

• Stroke — all drugs for Stroke →

Sponsor

Taipei Medical University Hospital

Who can join

Adults 20 to 80, any sex, with Stroke. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

After stroke, patients often experience motor deficits that interrupt normal lower extremity movement and gait function. Recent developments in neuroimaging have focus on the reasons why some patients recover well while some do poorly. However, there is still no consensus on the exact mechanisms involved in regaining the functions after rehabilitation. Application of repetitive transcranial magnetic stimulation (rTMS) to facilitate neural plasticity during stroke treatment has recently gained considerable attention. The possible mechanism through which rTMS acts is based on the interhemispheric competition (IHC) model, which explains that patients with stroke experience alterations in cortical excitability and exhibit abnormally high interhemispheric inhibition from the unaffected hemisphere to the affected hemisphere. The visual feedback training can improve postural control and enhance motor performance. Several rTMS studies have evaluated the lower extremity dysfunction following stroke, but few studies have explored the efficacy of applying rTMS on the lower extremities. We expect the study can help us to further exploration of the change of clinical function and cortical excitability following rTMS and visual feedback training in subjects with stroke. In addition, the results of this project will be provided for further rehabilitation programs in people with stroke.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Effectiveness of Repetitive Transcranial Magnetic Stimulation Combined with Visual Feedback Training in Improving Neuroplasticity and Lower Limb Function After Chronic Stroke
   Cheng H, Lin C, Tseng S, Peng C, et al · · 2022 · DOI 10.21203/rs.3.rs-2308395/v1