NCT03687450 is a NA clinical trial of RISE yoga-based program in Burnout, Professional, sponsored by Brigham and Women's Hospital.

Who is sponsoring NCT03687450?

NCT03687450 is sponsored by Brigham and Women's Hospital.

What drugs are being tested in NCT03687450?

Interventions in NCT03687450: RISE yoga-based program.

What condition does NCT03687450 study?

NCT03687450 studies Burnout, Professional, Anxiety, Depression, Stress.

Is NCT03687450 still recruiting?

NCT03687450 is currently completed. Last updated 23 July 2020.

Are results published for NCT03687450?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2020-07-23 · How we verify

NCT03687450

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Feasibility of a Yoga- and Mindfulness-Based Intervention for Resident Physicians

Completed NA Results posted Last updated 23 July 2020

What this trial tests

NA trial testing RISE yoga-based program in Burnout, Professional in 56 participants. Completed in 1 May 2020.

Timeline

1 November 2018

Primary endpoint
1 May 2020

1 May 2020

Quick facts

Lead sponsor	Brigham and Women's Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	56
Start date	1 November 2018
Primary completion	1 May 2020
Estimated completion	1 May 2020
Sites	1 location across United States

Drugs / interventions tested

RISE yoga-based program

Conditions studied

Burnout, Professional — all drugs for Burnout, Professional →
Anxiety — all drugs for Anxiety →
Depression — all drugs for Depression →
Stress — all drugs for Stress →

Sponsor

Brigham and Women's Hospital

Who can join

18 and older, any sex, with Burnout, Professional or Anxiety. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Feasibility of Attending the Yoga Program Primary · Post-program

Participants were ask to rate the feasibility of attending the yoga program on a visual analogue scale from 0 (not at all feasible) to 100 (very feasible). Only the intervention group rated feasibility since the control group was a waitlist control group and did not attend the program. The standard deviation of the mean score was calculated.

Group	Value	95% CI
Intervention (Yoga) Arm	28.9	± 25.6

Difference in Burnout Secondary · Post-program and 2-month follow-up

Maslach Burnout Inventory (short form, 2 items) - scores from 0-12; higher is more burnout

Baseline

Group	Value	95% CI
Intervention (Yoga) Arm	6.23	± 0.52
No-treatment Control Arm	6.33	± 0.92

Post-program

Group	Value	95% CI
Intervention (Yoga) Arm	5.65	± 0.50
No-treatment Control Arm	6.83	± 0.66

2-month follow-up

Group	Value	95% CI
Intervention (Yoga) Arm	5.72	± 0.53
No-treatment Control Arm	6.43	± 0.99

Difference in Professional Fulfillment Secondary · Baseline, post-program, and 2-month follow-up

Professional Fulfillment Index (PFI; 16 items) - scores from 0-4 for professional fulfillment scale; higher is more fulfillment

Baseline

Group	Value	95% CI
Intervention (Yoga) Arm	1.70	± 0.12
No-treatment Control Arm	1.53	± 0.18

Post-program

Group	Value	95% CI
Intervention (Yoga) Arm	1.35	± 0.14
No-treatment Control Arm	1.48	± 0.20

2-month follow-up

Group	Value	95% CI
Intervention (Yoga) Arm	1.38	± 0.10
No-treatment Control Arm	1.56	± 0.21

Difference in Resident Well-being Secondary · Baseline, post-program, and 2-month follow-up

Resident Well-Being Index (7 items) - scores from 0-7; higher is worse wellbeing

Baseline

Group	Value	95% CI
Intervention (Yoga) Arm	4.19	± 0.30
No-treatment Control Arm	4.08	± 0.58

Post-program

Group	Value	95% CI
Intervention (Yoga) Arm	3.15	± 0.33
No-treatment Control Arm	3.62	± 0.35

2-month follow-up

Group	Value	95% CI
Intervention (Yoga) Arm	3.40	± 0.37
No-treatment Control Arm	3.25	± 0.49

Difference in Resilience Secondary · Baseline, post-program, and 2-month follow-up

Resilience Scale (RS-14; 14 items) - scores from 14-98; higher more resilience

Baseline

Group	Value	95% CI
Intervention (Yoga) Arm	70.61	± 2.26
No-treatment Control Arm	71.20	± 3.14

Post-program

Group	Value	95% CI
Intervention (Yoga) Arm	76.32	± 1.79
No-treatment Control Arm	72.07	± 3.02

2-month follow-up

Group	Value	95% CI
Intervention (Yoga) Arm	72.61	± 1.76
No-treatment Control Arm	72.43	± 3.22

Difference in Mindfulness Secondary · Baseline, post-program, and 2-month follow-up

Five Facet Mindfulness Questionnaire (FFMQ; short form, 15 items) - scores from 15-75; higher score means more mindfulness

Baseline

Group	Value	95% CI
Intervention (Yoga) Arm	48.54	± 1.14
No-treatment Control Arm	48.60	± 1.92

Post-program

Group	Value	95% CI
Intervention (Yoga) Arm	54.27	± 1.42
No-treatment Control Arm	49.73	± 1.54

2-month follow-up

Group	Value	95% CI
Intervention (Yoga) Arm	51.83	± 0.99
No-treatment Control Arm	48.56	± 1.49

Difference in Stress Secondary · Baseline, post-program, and 2-month follow-up

Perceived Stress Scale (PSS; 10 items) - scores from 0-40; higher is more stress

Baseline

Group	Value	95% CI
Intervention (Yoga) Arm	19.74	± 1.09
No-treatment Control Arm	20.69	± 1.88

Post-program

Group	Value	95% CI
Intervention (Yoga) Arm	16.15	± 1.38
No-treatment Control Arm	18.23	± 1.36

2-month follow-up

Group	Value	95% CI
Intervention (Yoga) Arm	16.52	± 0.85
No-treatment Control Arm	18.88	± 1.90

Difference in Depression Secondary · Baseline, post-program, and 2-month follow-up

Patient Reported Outcomes Measurement Information System (PROMIS) Depression (short form: depression-4) - scores from 4-20, higher is more depression

Baseline

Group	Value	95% CI
Intervention (Yoga) Arm	7.56	± 0.64
No-treatment Control Arm	7.15	± 1.13

Post-program

Group	Value	95% CI
Intervention (Yoga) Arm	6.48	± 0.54
No-treatment Control Arm	7.23	± 0.75

2-month follow-up

Group	Value	95% CI
Intervention (Yoga) Arm	7.24	± 0.61
No-treatment Control Arm	7.81	± 0.94

Difference in Sleep Quality Secondary · Baseline, post-program, and 2-month follow-up

PROMIS Sleep Disturbance (short form, 4 items) - scores from 4-20, higher is more sleep disturbance

Baseline

Group	Value	95% CI
Intervention (Yoga) Arm	10.38	± 0.62
No-treatment Control Arm	11.62	± 1.28

Post-program

Group	Value	95% CI
Intervention (Yoga) Arm	8.73	± 0.59
No-treatment Control Arm	9.92	± 0.91

2-month follow-up

Group	Value	95% CI
Intervention (Yoga) Arm	8.96	± 0.61
No-treatment Control Arm	8.50	± 1.02

Difference in Anxiety Secondary · Baseline, post-program, and 2-month follow-up

Patient Reported Outcomes Measurement Information System (PROMIS) Anxiety (short form: anxiety-4) - scores from 4-20, higher is more anxiety

Baseline

Group	Value	95% CI
Intervention (Yoga) Arm	9.65	± 0.60
No-treatment Control Arm	10.00	± 1.00

Post-program

Group	Value	95% CI
Intervention (Yoga) Arm	8.54	± 0.59
No-treatment Control Arm	9.15	± 0.94

2-month follow-up

Group	Value	95% CI
Intervention (Yoga) Arm	8.96	± 0.57
No-treatment Control Arm	7.94	± 0.81

Differences in Professional Fulfillment - Burnout Sub-Item Secondary · Baseline, post-program, and 2-month follow-up

Professional Fulfillment Index (PFI; 16 items) - scores from 0-4 for the burnout scale; higher is more burnout

Baseline

Group	Value	95% CI
Intervention (Yoga) Arm	2.26	± 0.13
No-treatment Control Arm	1.97	± 0.23

Post-program

Group	Value	95% CI
Intervention (Yoga) Arm	2.47	± 0.15
No-treatment Control Arm	2.13	± 0.19

2-month follow-up

Group	Value	95% CI
Intervention (Yoga) Arm	2.31	± 0.11
No-treatment Control Arm	2.02	± 0.22

Sponsor's own description

The investigators aim to initiate and complete the first investigation of the effect of a yoga-based program on resident physicians' psychological health using a randomized controlled trial to assess feasibility of the program in this population and measure outcomes across several domains. To meet the goals of the proposed project the investigators have identified 3 specific aims: Specific Aim 1: Assess the acceptability and feasibility of the yoga program through measuring participation and conducting standardized interviews with a subset of yoga participants. Specific Aim 2: Evaluate the effect of the yoga program on resident physicians' stress, burnout, resilience, mindfulness, mood, depression, anxiety, and sleep quality using quantitative self-report measures. Specific Aim 3. Examine whether outcome measures were perceived as relevant to the participants' work environment and were not burdensome as to the length and content of the program.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Mindfulness-based psychological interventions for improving mental well-being in medical students and junior doctors.
Sekhar P, Tee QX, Ashraf G, Trinh D, et al · · 2021 · cited 23× · PMID 34890044 · DOI 10.1002/14651858.cd013740.pub2
Evaluation of a Yoga-Based Mind-Body Intervention for Resident Physicians: A Randomized Clinical Trial.
Loewenthal J, Dyer NL, Lipsyc-Sharf M, Borden S, et al · · 2021 · cited 17× · PMID 33786209 · DOI 10.1177/21649561211001038
Development and Feasibility Testing of a Brief Yoga Module on Well-being and Cognition of Postgraduate Mental Healthcare Students in Tertiary Settings.
Hakkim A, Jagannathan A, Bhargav H, Jasti N, et al · · 2021 · cited 1× · PMID 35017865 · DOI 10.4103/ijoy.ijoy_87_21

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03687450 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Brigham and Women's Hospital
Last refreshed: 23 July 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03687450.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing

NCT03687450

Quick facts

Drugs / interventions tested

Conditions studied

Sponsor

Who can join

Results — posted to ClinicalTrials.gov

Sponsor's own description

Publications & conference data

Related trials

Other recruiting trials for Burnout, Professional

Other Brigham and Women's Hospital trials

Verify against primary sources