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NCT03682614
Effect of Intrauterine Injection of HCG on Clinical Pregnancy Outcome in Repeated Implantation Failure Patients
NA trial testing HCG in Infertility in 47 participants. Completed in 16 October 2019.
18 August 2019
Quick facts
| Lead sponsor | Reproductive & Genetic Hospital of CITIC-Xiangya |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 47 |
| Start date | 10 December 2018 |
| Primary completion | 18 August 2019 |
| Estimated completion | 16 October 2019 |
| Sites | 1 location across China |
Drugs / interventions tested
- HCG
- culture medium
Conditions studied
- Infertility — all drugs for Infertility →
Sponsor
Reproductive & Genetic Hospital of CITIC-Xiangya
Who can join
Adults 18 to 36, female only, with Infertility. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Repeated implantation failure（RIF） is a insurmountable bottleneck in assisted reproductive technology, many studies have considered that the cause of two-thirds of implantation failure is the decreased endometrial receptivity. After exclude some major local immune factors(NK,CD138 cells) and implantation window out of phase, There are still a part of patients infertile .Human chorionic gonadotropin (hCG) is an early pre-implantation signal molecule secreted by the embryo, it can promote endometrial proliferation, increase blood flow and promote embryonic adhesion and inhibit self-regulated apoptosis of trophoblast cells. Previous studies showed that: intrauterine injection of HCG before embryo transfer can improve clinical outcomes in IVF/Intracytoplasmic sperm injection(ICSI). But some studies found that the intrauterine injection of HCG can not significantly improve the success rate of blastocyst transfer, and the reason may be the intrauterine injection of HCG time is too late to significantly increase the implantation rate. Would ahead of intrauterine injection of HCG be more effective? Thus, the patients of repeated implantation frozen embryo cycle according to the random principle accepted two kinds of transplants ways: ①intrauterine injection of HCG before blastocyst transfer; ②blastocyst transfer. Try to understand whether intrauterine injection of HCG can significantly improve the clinical pregnancy rate of blastocyst transfer in repeated implantation failure patients.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03682614
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Related trials
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Other recruiting trials for Infertility
Currently open trials in the same condition.
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- NCT07153367 — Using a Fixed Dosage of Follitropin Delta for Ovarian Stimulation for Intrauterine Insemination: Rekovelle for Intrauter · Phase 2 · recruiting
Other Reproductive & Genetic Hospital of CITIC-Xiangya trials
Trials by the same sponsor.
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- NCT04639505 — Predictive Value of New AMH Test Method for Ovarian Response · completed
- NCT04538560 — Preimplantation Genetic Testing for Aneuploidy of Polar Bodies · NA · unknown
- NCT03910582 — Personalized FET in RIF Patients With Displaced Dating · NA · unknown
- NCT04178135 — Recombinant LH Supplementation Timing Strategies (From Day 1 or Day 6) to a Standard GnRH Agonist Long Protocol in Subse · NA · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03682614 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Reproductive & Genetic Hospital of CITIC-Xiangya
- Last refreshed: 11 January 2022
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