NCT03682198 is a NA clinical trial of NIRS measurements on skin, skull and dura in Neurosurgery, sponsored by University Hospital Bispebjerg and Frederiksberg.

Who is sponsoring NCT03682198?

NCT03682198 is sponsored by University Hospital Bispebjerg and Frederiksberg.

What drugs are being tested in NCT03682198?

Interventions in NCT03682198: NIRS measurements on skin, skull and dura, Phenylephrine's effect on brain oxygenation, Normal vs. high inspired oxygen.

What condition does NCT03682198 study?

NCT03682198 studies Neurosurgery, Elective Craniotomy, General Anaesthesia.

Is NCT03682198 still recruiting?

NCT03682198 is currently completed. Last updated 3 November 2020.

Last reviewed 2020-11-03 · How we verify

NCT03682198

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Neuro-Ox 2018: Assessment of Cerebral Oxygenation Under Three Clinically Relevant Conditions

Completed NA Last updated 3 November 2020

What this trial tests

NA trial testing NIRS measurements on skin, skull and dura in Neurosurgery in 18 participants. Completed in 1 October 2020.

Timeline

24 September 2018

Primary endpoint
1 October 2020

1 October 2020

Quick facts

Lead sponsor	University Hospital Bispebjerg and Frederiksberg
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	basic science
Enrollment	18
Start date	24 September 2018
Primary completion	1 October 2020
Estimated completion	1 October 2020
Sites	1 location across Denmark

Drugs / interventions tested

NIRS measurements on skin, skull and dura
Phenylephrine's effect on brain oxygenation — full drug profile →
Normal vs. high inspired oxygen — full drug profile →

Conditions studied

Neurosurgery — all drugs for Neurosurgery →
Elective Craniotomy — all drugs for Elective Craniotomy →
General Anaesthesia — all drugs for General Anaesthesia →

Sponsor

University Hospital Bispebjerg and Frederiksberg

Who can join

18 and older, any sex, with Neurosurgery or Elective Craniotomy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a prospective observational study, consisting of 3 substudies carried out during elective neurosurgery under general anaesthesia. Each participant will take part in all 3 substudies. First, the capability of Near Infra Red Spectroscopy (NIRS) to measure the brain oxygenation is examined. A NIRS-electrode is placed on forehead skin, on the skull, and on dura. Secondly, a small dose of Phenylephrine is given, and the brain oxygenation is measured by a Clark-electrode and a NIRS-electrode, to see how Phenylephrine affects these measurements. In the third substudy, the brain oxygenations' (NIRS and Licox) response to an inspired oxygen fraction of 0.30 vs. 0.80 is investigated.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Impact of hyperoxia and phenylephrine on cerebral oxygenation: An experimental clinical study.
Pedersen SS, Meyhoff CS, Olsen MH, Stisen ZR, et al · · 2023 · cited 6× · PMID 36112064 · DOI 10.1111/aas.14149

Verify or expand the search:

Other recruiting trials for Neurosurgery

Currently open trials in the same condition.

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Other University Hospital Bispebjerg and Frederiksberg trials

Trials by the same sponsor.

NCT07060586 — The Effect of Sphenopalatine Ganglion Block on Headache and Vasalgia · NA · completed
NCT06911411 — PALLIATIVE ASSESSMENT COHORT IN THE GERIATRIC EMERGENCY SETTING · not yet recruiting
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NCT06532825 — Cardiac Autonomic Dysfunction As a Sign of Irreversible Advanced Heart Failure · recruiting
NCT06184581 — Lithium Versus Lamotrigine in Bipolar Disorder, Type II · Phase 4 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03682198 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital Bispebjerg and Frederiksberg
Last refreshed: 3 November 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03682198.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing