Last reviewed · How we verify
NCT03681977: MP-Persona
Clinical Outcomes of MP Persona vs. Persona Knee-PS
NA trial testing Zimmer MP Persona in Osteoarthritis, Knee in 162 participants. Enrolling by invitation.
31 December 2025
Quick facts
| Lead sponsor | Lady Davis Institute |
|---|---|
| Phase | NA |
| Status | ENROLLING BY INVITATION |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 162 |
| Start date | 1 September 2019 |
| Primary completion | 31 December 2025 |
| Estimated completion | 30 June 2026 |
| Sites | 3 locations across Canada |
Drugs / interventions tested
- Zimmer MP Persona
- Zimmer Persona Knee-PS
Conditions studied
- Osteoarthritis, Knee — all drugs for Osteoarthritis, Knee →
Sponsor
Lady Davis Institute
Who can join
Adults 18 to 80, any sex, with Osteoarthritis, Knee. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Knee osteoarthritis (OA) is a highly prevalent condition that results in substantial pain and loss of function. The end stage treatment for knee OA is total knee arthroplasty (TKA), a common and safe procedure typically performed for relief of symptoms. However, an increasing number of patients are complaining about their TKA due to altered sensations between their previous joint and the implant. Although several designs have been proposed to improve these outcomes, the knee kinematics after TKA remains different from physiological kinematics. The Medial Pivot TKA design was introduced to closely mimic normal knee kinematics and create the natural feeling of the knee. This study is intended to evaluate the clinical effectiveness and ability to restore knee motion of two TKA devices: the Medial Pivot Persona TKA Zimmer design with the traditional Zimmer Persona Knee-PS. The investigator's hypothesis is that the Medial Pivot design will results in better patient outcomes and restore knee motion at natural parameters.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT03681977
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Osteoarthritis, Knee
Currently open trials in the same condition.
- NCT07509307 — AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee · Phase 3 · recruiting
- NCT06488144 — Rehabilitation for Arthritis of The Knee: mainTaining Improvement for Veterans · Phase 3 · recruiting
- NCT07386561 — Virtual Reality Therapy and Non-Sleep Deep Rest Relaxation After Joint Arthroplasty · NA · active not recruiting
- NCT07514598 — Effect of J-Shaped Incision After Total Knee Arthroplasty (J-TKA) · NA · active not recruiting
- NCT07058623 — Nurse-Led Telehealth vs In-Person Follow-Up After Total Knee Replacement · NA · recruiting
Other Lady Davis Institute trials
Trials by the same sponsor.
- NCT06373263 — Evaluating Tools to Communicate Scleroderma Research Results to Patients - Trial #1 · NA · not yet recruiting
- NCT06772896 — Evaluating the Effect of Questionnaire Context on the Reporting of Somatic Items Among People With Systemic Sclerosis · NA · completed
- NCT06588101 — Clinical Trial Recruitment and Retention Strategies for Family Members in the ICU · NA · recruiting
- NCT05366088 — RCT of MBCT vs HEP for Late-Life Depression · NA · terminated
- NCT06189118 — Online MBCT vs HEP for Depressive Symptoms in Older Adults: RCT · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03681977 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Lady Davis Institute
- Last refreshed: 12 July 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03681977.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing