Last reviewed · How we verify
NCT03681873
Validation of Low Dose CT for Diagnosis of Lung Nodules
NA trial testing Extremely Low Dose CT in Cancer in 78 participants. Completed in 7 September 2021.
2 September 2020
Quick facts
| Lead sponsor | Children's Hospital Medical Center, Cincinnati |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 78 |
| Start date | 30 November 2018 |
| Primary completion | 2 September 2020 |
| Estimated completion | 7 September 2021 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Extremely Low Dose CT
Conditions studied
- Cancer — all drugs for Cancer →
- Metastasis to Lung — all drugs for Metastasis to Lung →
Sponsor
Children's Hospital Medical Center, Cincinnati
Who can join
Adults 4 to 20, any sex, with Cancer or Metastasis to Lung. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The investigators have developed an extremely low dose computed tomography (CT) protocol that on preliminary testing has an effective dose in the range of two chest radiographs. The investigators plan to test this exam in patients with known or suspected cancer undergoing clinically indicated chest CT.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Comparison of 0.3-mSv CT to Standard-Dose CT for Detection of Lung Nodules in Children and Young Adults With Cancer.
Thapaliya S, Gilligan LA, Brady SL, Anton CG, et al · · 2021 · cited 12× · PMID 34232694 · DOI 10.2214/ajr.21.26183 -
Targeted Lung Premetastasis Niche: Mechanisms, Strategies, and Application.
Cao C, Lu D, Li H, Pan S, et al · · 2025 · cited 2× · PMID 40470380 · DOI 10.1002/mco2.70248
Verify or expand the search:
- PubMed search for NCT03681873
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03681873 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Children's Hospital Medical Center, Cincinnati
- Last refreshed: 15 August 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03681873.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing