Who is sponsoring NCT03680638?

NCT03680638 is sponsored by The University of Texas at Arlington.

What drugs are being tested in NCT03680638?

Interventions in NCT03680638: Control (Lactated Ringer's), Tempol, Apocynin, Allopurinol.

What condition does NCT03680638 study?

NCT03680638 studies Cardiovascular Diseases, Cardiovascular Risk Factor, Vasodilation.

Is NCT03680638 still recruiting?

NCT03680638 is currently completed. Last updated 21 September 2018.

Last reviewed 2018-09-21 · How we verify

NCT03680638

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Effect of Antioxidants on Skin Blood Flow During Local Heating

Completed Phase 1 Last updated 21 September 2018

What this trial tests

Phase 1 trial testing Control (Lactated Ringer's) in Cardiovascular Diseases in 44 participants. Completed in 9 October 2017.

Timeline

7 September 2016

Primary endpoint
9 October 2017

9 October 2017

Quick facts

Lead sponsor	The University of Texas at Arlington
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	basic science
Enrollment	44
Start date	7 September 2016
Primary completion	9 October 2017
Estimated completion	9 October 2017
Sites	1 location across United States

Drugs / interventions tested

Control (Lactated Ringer's)
Tempol — full drug profile →
Apocynin — full drug profile →
Allopurinol (ALLOPURINOL) — full drug profile →

Conditions studied

Cardiovascular Diseases — all drugs for Cardiovascular Diseases →
Cardiovascular Risk Factor — all drugs for Cardiovascular Risk Factor →
Vasodilation — all drugs for Vasodilation →

Sponsor

The University of Texas at Arlington

Who can join

Adults 18 to 35, any sex, with Cardiovascular Diseases or Cardiovascular Risk Factor. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this study is to examine possible mechanisms of impaired vasodilaton in obese and Black/African American men and women as possible links to the elevated prevalence of cardiovascular dysfunction and disease. The main targets in this study are sources of oxidative stress.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Novel therapeutics for the treatment of hypertension and its associated complications: peptide- and nonpeptide-based strategies.
Ghatage T, Goyal SG, Dhar A, Bhat A. · · 2021 · cited 54× · PMID 33731923 · DOI 10.1038/s41440-021-00643-z
Precision Medicine: Therapeutically Targeting Mitochondrial Alterations in Heart Failure.
Parker AM, Lees JG, Murray AJ, Velagic A, et al · · 2025 · cited 5× · PMID 40845481 · DOI 10.1016/j.jacbts.2025.101345

Verify or expand the search:

Other recruiting trials for Cardiovascular Diseases

Currently open trials in the same condition.

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NCT07324278 — Hybrid Stroke Rehab With Mirror Priming · NA · recruiting
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Other The University of Texas at Arlington trials

Trials by the same sponsor.

NCT07219355 — Virtual Reality Lethal Means Safety Training · NA · recruiting
NCT07313410 — Using Near-Infrared Light to Better Understand Peripheral Artery Disease · recruiting
NCT07196436 — Asthma Intervention With Residential Ventilation and Air Cleaner (AIRVAC) Study · NA · recruiting
NCT06857877 — Arlington Aging Study · recruiting
NCT06497413 — Brain Vascular and Neurocognitive Health · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03680638 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by The University of Texas at Arlington
Last refreshed: 21 September 2018

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03680638.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing