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NCT03678831: MEDADIPO
Characteristics of Marrow Fatty Cells in the Ageing of Bone and Joints, Osteoarthritis and Osteoporosis
trial testing tissue in Osteoarthritis, Knee in 45 participants. Completed in 11 March 2024.
11 March 2024
Quick facts
| Lead sponsor | University Hospital, Lille |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 45 |
| Start date | 30 June 2020 |
| Primary completion | 11 March 2024 |
| Estimated completion | 11 March 2024 |
| Sites | 1 location across France |
Drugs / interventions tested
- tissue
Conditions studied
- Osteoarthritis, Knee — all drugs for Osteoarthritis, Knee →
- Prosthesis User — all drugs for Prosthesis User →
Sponsor
University Hospital, Lille
Who can join
Adults 18 to 85, female only, with Osteoarthritis, Knee or Prosthesis User. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Obesity and other associated complications promote the development and the progression of osteoarthritis. The subcutaneous and abdominal fat release several factors that alter bone and the cartilage. The role of the marrow fat in close connection with bone has not been defined yet, whereas cellular and animal models indicate that this fat depot modifies bone and cartilage. The aim of the study is to define if the marrow fat produces more joint-altering factors by comparison with subcutaneous fat. This fat depot can be characterized from removed pieces during the prosthetic surgery of the knee. Measuring before surgery the body weight, waist and hip circumferences, blood pressure, glucose, insulin and lipids in blood will also allow to determine if obesity and/or type 2 diabetes make this fat more dangerous for the joint. Such research will allow the elaboration of new therapeutic strategies in osteoarthritis.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Adipose tissue in bone regeneration - stem cell source and beyond.
Labusca L. · · 2022 · cited 9× · PMID 35949397 · DOI 10.4252/wjsc.v14.i6.372
Verify or expand the search:
- PubMed search for NCT03678831
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Osteoarthritis, Knee
Currently open trials in the same condition.
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Other University Hospital, Lille trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03678831 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Lille
- Last refreshed: 5 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03678831.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing