NCT03678181

Increasing Engagement and Improving HIV Outcomes Via HealthMPowerment

Completed NA Results posted Last updated 27 September 2024

What this trial tests

NA trial testing Information Resources in HIV Infections in 750 participants. Completed in 15 October 2023.

Timeline

7 July 2020

Primary endpoint
15 October 2023

15 October 2023

Quick facts

Lead sponsor	University of Pennsylvania
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	750
Start date	7 July 2020
Primary completion	15 October 2023
Estimated completion	15 October 2023
Sites	3 locations across United States

Drugs / interventions tested

• Information Resources
• Social Support
• HIV Testing

Conditions studied

• HIV Infections — all drugs for HIV Infections →
• Sexually Transmitted Diseases — all drugs for Sexually Transmitted Diseases →
• Stigma, Social — all drugs for Stigma, Social →

Sponsor

University of Pennsylvania

Who can join

Adults 15 to 29, male only, with HIV Infections or Sexually Transmitted Diseases. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Percent of Participants Reporting Changes in Their HIV Testing Behavior Using Self-report Questionnaires Primary · 12 month

The investigators will estimate the proportion of participants who test at least twice for HIV over a 12-month period by intervention group.

Group	Value	95% CI
Information-Only Arm	185
HMP 2.0 Arm	171
Peer-referred HMP Network Arm	2

Percent of Participants Reporting Viral Suppression Using Self-Report Questionnaires Primary · 12 month

The investigators will estimate the proportion of participants living with HIV who achieve viral suppression over a 12-month period by intervention group.

Group	Value	95% CI
Information-Only Arm	45
HMP 2.0 Arm	60
Peer-referred HMP Network Arm	60
Information-Only Arm	29
HMP 2.0 Arm	15
Peer-referred HMP Network Arm	21

Number of Days in the Prior Week That Participants Self-report Missing at Least One Dose of Their Adherence to Antiretroviral Therapy (ART) Using a Self-Reported Questionnaire Secondary · 12 month

The investigators will test the proportion of the HIV-positive sample that adheres to their HIV care regimen during the 12-month follow-up.

Group	Value	95% CI
Information-Only Arm	0.92	± 1.65
HMP 2.0 Arm	0.96	± 1.75
Peer-referred HMP Network Arm	1.21	± 2.06

Percent of Participants Reporting PrEP Uptake Using Self-Report Questionnaires Secondary · 12 month

The investigators will test the proportion of the HIV-negative sample that reports using PrEP by the 12-month follow-up.

Group	Value	95% CI
Information-Only Arm	77
HMP 2.0 Arm	74
Peer-referred HMP Network Arm	0
Information-Only Arm	50
HMP 2.0 Arm	42
Peer-referred HMP Network Arm	1
Information-Only Arm	78
HMP 2.0 Arm	73
Peer-referred HMP Network Arm	1

Sponsor's own description

The overall goal of this 3-arm randomized trial is to test whether a network-driven online intervention tailored for intersectional stigma amelioration can elicit online social support, promote intervention engagement, and mitigate the impact of multiple stigmas on HIV-related outcomes among young Black and/or Latino men who have sex with men and transgender women.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

1. Behavioural interventions delivered through interactive social media for health behaviour change, health outcomes, and health equity in the adult population.
   Petkovic J, Duench S, Trawin J, Dewidar O, et al · · 2021 · cited 78× · PMID 34057201 · DOI 10.1002/14651858.cd012932.pub2
2. Increasing HIV Testing and Viral Suppression via Stigma Reduction in a Social Networking Mobile Health Intervention Among Black and Latinx Young Men and Transgender Women Who Have Sex With Men (HealthMpowerment): Protocol for a Randomized Controlled Trial.
   Muessig KE, Golinkoff JM, Hightow-Weidman LB, Rochelle AE, et al · · 2020 · cited 23× · PMID 33325838 · DOI 10.2196/24043
3. A Suicide Prevention Intervention for Emerging Adult Sexual and Gender Minority Groups: Protocol for a Pilot Hybrid Effectiveness Randomized Controlled Trial.
   Brown LA, Webster JL, Tran JT, Wolfe JR, et al · · 2023 · cited 6× · PMID 37773618 · DOI 10.2196/48177
4. Characterizing Intersectional Stigma and Its Association With Mental Health Outcomes Among Sexual and Gender-Diverse Youth Assigned Male at Birth in the United States.
   Tran JT, Choi SK, Hightow-Weidman LB, Muessig KE, et al · · 2025 · PMID 41086045 · DOI 10.1521/aeap.2025.37.5.347