NCT03678012 is a EARLY_PHASE1 clinical trial of Ferumoxytol/Hydrogen peroxide in Dental Caries, sponsored by University of Pennsylvania.

Who is sponsoring NCT03678012?

NCT03678012 is sponsored by University of Pennsylvania.

What drugs are being tested in NCT03678012?

Interventions in NCT03678012: Ferumoxytol/Hydrogen peroxide, Hydrogen Peroxide, Water.

What condition does NCT03678012 study?

NCT03678012 studies Dental Caries.

Is NCT03678012 still recruiting?

NCT03678012 is currently completed. Last updated 19 September 2018.

Last reviewed 2018-09-19 · How we verify

NCT03678012

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Evaluation of Anti-biofilm Effects of Ferumoxytol (Feraheme) Using an in Situ Biofilm Demineralization Model

Completed EARLY_PHASE1 Last updated 19 September 2018

What this trial tests

EARLY_PHASE1 trial testing Ferumoxytol/Hydrogen peroxide in Dental Caries in 16 participants. Completed in 16 August 2018.

Timeline

7 June 2018

Primary endpoint
16 August 2018

16 August 2018

Quick facts

Lead sponsor	University of Pennsylvania
Phase	EARLY_PHASE1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	triple
Primary purpose	prevention
Enrollment	16
Start date	7 June 2018
Primary completion	16 August 2018
Estimated completion	16 August 2018
Sites	2 locations across United States

Drugs / interventions tested

Ferumoxytol/Hydrogen peroxide — full drug profile →
Hydrogen Peroxide — full drug profile →
Water (WATER) — full drug profile →

Conditions studied

Dental Caries — all drugs for Dental Caries →

Sponsor

University of Pennsylvania

Who can join

Adults 18 to 85, any sex, with Dental Caries. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

To evaluate the effects of a clinically approved and commercially available iron oxide formulation Ferumoxytol (Feraheme®) to control cariogenic biofilms and enamel demineralization. This study will be testing topical application of Ferumoxytol extra-orally using a standard in situ biofilm demineralization model.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Screening strategies for quorum sensing inhibitors in combating bacterial infections.
Lu L, Li M, Yi G, Liao L, et al · · 2022 · cited 54× · PMID 35573879 · DOI 10.1016/j.jpha.2021.03.009
Nanozymes for Liver Disease Therapy: Advances in Catalytic Activity, Targeting Strategies, and Clinical Translation.
Meng X, Zhu G, Sun S, Yao W, et al · · 2026 · PMID 41762712 · DOI 10.1002/advs.74590

Verify or expand the search:

Other recruiting trials for Dental Caries

Currently open trials in the same condition.

NCT06787261 — Involvement of Archaea in Carious Disease · NA · recruiting
NCT06753669 — Mothers' Action Project for Child Health · NA · recruiting
NCT07431463 — Effects of Different Remineralization Agents on the Progression of Non-Cavitated Approximal Carious Lesions in Primary T · NA · active not recruiting
NCT07134114 — Occlusal Impact of Hall Crowns in Primary Molars · NA · recruiting
NCT07181967 — SDF vs Fluoride Varnish for Streptococcus Mutans Reduction in Children · NA · recruiting

Other University of Pennsylvania trials

Trials by the same sponsor.

NCT06081153 — Mechanistic Clinical Trial of PCSK9 Inhibition for AAA · EARLY_PHASE1 · not yet recruiting
NCT07415772 — Effect of cTBS on Startle and TMS-evoked BOLD · NA · not yet recruiting
NCT07489430 — DaxibotulinumtoxinA for Blepharospasm · Phase 2 · not yet recruiting
NCT07463131 — Negative Income Tax Trial · NA · not yet recruiting
NCT06645769 — Na-Phenylbutyrate VAscular Trial · EARLY_PHASE1 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03678012 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Pennsylvania
Last refreshed: 19 September 2018

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03678012.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing