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The Relationship Between Autobiographical Memory and Motivation
NA trial testing Guided Autobiographical Memory Recall in Psychosis in 31 participants. Completed in 19 February 2020.
| Lead sponsor | King's College London |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | basic science |
| Enrollment | 31 |
| Start date | 18 May 2017 |
| Primary completion | 31 March 2018 |
| Estimated completion | 19 February 2020 |
| Sites | 2 locations across United Kingdom |
King's College London
Adults 18 to 65, any sex, with Psychosis. Patients with the condition only — healthy volunteers not accepted.
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
A rating on a visual analogue scale assessing motivation to repeat the same activity recalled in the future. The scale is rated from 0-100 and a higher score indicated better outcome.
| Group | Value | 95% CI |
|---|---|---|
| Intervention | 81.01 | 69.21 – 85.86 |
| Control | 72.89 | 65.12 – 88.38 |
A rating on a visual analogue scale assessing how pleasant that activity is anticipated to be if repeated. The scale is rated from 0-100 and a higher score indicated better outcome.
| Group | Value | 95% CI |
|---|---|---|
| Intervention | 84.35 | ± 3.05 |
| Control | 86.58 | ± 4.76 |
People with a diagnosis of psychosis often experience low motivation and pleasure when thinking about doing future activities. This leads, quite understandably, to doing fewer activities they used to enjoy and not taking up opportunities to do new activities. One model suggests that this may be partly due to difficulties using memories of previous events to help boost motivation and anticipation before a future activity. Research shows that people with psychosis may recall previous events in less detail. These memories therefore may not be as helpful as they could be for motivation. This study will investigate this by asking people with experience of psychosis and low motivation who are seen by a care team in South London and Maudsley NHS Trust to attend two research sessions. In the first session the participants will be asked to recall memories of events from their lives and the researcher will assess how detailed the memories are and how much the participant refers to the past and future. Alongside this task the participants will also be asked to complete measures of symptoms such as low pleasure and motivation as well as a measure of depression. These will be used to find out if the detail and specificity of the memories are related to these symptoms in people with psychosis. The second half of the study will then investigate whether additional prompts to support positive memory retrieval can increase the specificity of this and subsequently improve mood, motivation and self-belief. Participants will be randomised to one of two groups. The clinical group will be guided through their memory recall using prompts and a control group will be asked to recall positive memories without prompts. If the investigators show that supporting memory recall is beneficial then memories for past events may be an important target for future therapies.
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
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