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NCT03676075
A Multi-center Trial to Establish a Model for the Early Diagnosis of Colorectal Cancer by the Detection of 5-hydroxymethylcytosine (5-hmC) in Plasma Cell-free DNA
trial in Colorectal Cancer in 1,500 participants. Status unknown.
30 June 2019
Quick facts
| Lead sponsor | Fudan University |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 1,500 |
| Start date | 1 December 2018 |
| Primary completion | 30 June 2019 |
| Estimated completion | 30 June 2019 |
| Sites | 1 location across China |
Conditions studied
- Colorectal Cancer — all drugs for Colorectal Cancer →
- Adenoma — all drugs for Adenoma →
Sponsor
Fudan University
Who can join
18 and older, any sex, with Colorectal Cancer or Adenoma. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In this study, the investigators establish a model for the early diagnosis of colorectal cancer based on the detection of 5-hydroxymethylcytosine (5-hmC) in training group and validate the effectiveness of the model using a validation group recruited from multiple centers.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
5-Hydroxymethylcytosine modifications in circulating cell-free DNA: frontiers of cancer detection, monitoring, and prognostic evaluation.
Song D, Zhang Z, Zheng J, Zhang W, et al · · 2025 · cited 9× · PMID 40055844 · DOI 10.1186/s40364-025-00751-9 -
A 5-Hydroxymethylcytosine-Based Noninvasive Model for Early Detection of Colorectal Carcinomas and Advanced Adenomas: The METHOD-2 Study.
Chang W, Zhang Z, Jia B, Ding K, et al · · 2024 · cited 8× · PMID 38814264 · DOI 10.1158/1078-0432.ccr-24-0199 -
Cell-Free DNA Hydroxymethylation in Cancer: Current and Emerging Detection Methods and Clinical Applications.
Li JJN, Liu G, Lok BH. · · 2024 · cited 2× · PMID 39336751 · DOI 10.3390/genes15091160
Verify or expand the search:
- PubMed search for NCT03676075
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03676075 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Fudan University
- Last refreshed: 18 September 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03676075.
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