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NCT03668015
Xylitol and Sorbitol Effects on the Oral Microbiome
NA trial testing Xylitol then Sorbitol gum in Human Microbiome in 29 participants. Completed in 4 June 2015.
4 June 2015
Quick facts
| Lead sponsor | The University of The West Indies |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | triple |
| Primary purpose | prevention |
| Enrollment | 29 |
| Start date | 5 March 2015 |
| Primary completion | 4 June 2015 |
| Estimated completion | 4 June 2015 |
Drugs / interventions tested
- Xylitol then Sorbitol gum
- Sorbitol then Xylitol gum
Conditions studied
- Human Microbiome — all drugs for Human Microbiome →
Sponsor
The University of The West Indies
Who can join
18 and older, any sex, with Human Microbiome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Chewing gum containing xylitol may help prevent caries by reducing levels of mutans streptococci (MS) and lactobacilli in saliva and plaque. Very little is known about other species which are possibly beneficial to oral health. In this study, the investigators employed high-throughput sequencing of the 16S ribosomal ribonucleic acid (rRNA) gene to profile microbial communities of saliva and plaque following short-term consumption of xylitol and sorbitol containing chewing gum. Participants (n = 30) underwent a washout period and were randomly assigned to one of two groups. Each group chewed either xylitol or sorbitol gum for 3 weeks, before undergoing a second four-week washout period after which they switched to the alternate gum for three weeks.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Xylitol and sorbitol effects on the microbiome of saliva and plaque.
Rafeek R, Carrington CVF, Gomez A, Harkins D, et al · · 2019 · cited 22× · PMID 30598728 · DOI 10.1080/20002297.2018.1536181
Verify or expand the search:
- PubMed search for NCT03668015
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Other The University of The West Indies trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03668015 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The University of The West Indies
- Last refreshed: 5 October 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03668015.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing