Who is sponsoring NCT03665818?

NCT03665818 is sponsored by Xuanwu Hospital, Beijing.

What drugs are being tested in NCT03665818?

Interventions in NCT03665818: oral appliance treatment.

What condition does NCT03665818 study?

NCT03665818 studies Sleep Apnea Syndromes, Atherosclerosis, Carotid Plaque.

Is NCT03665818 still recruiting?

NCT03665818 is currently completed. Last updated 22 July 2020.

Last reviewed 2020-07-22 · How we verify

NCT03665818

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Influence of Mandibular Advancement Device Treating OSAHS on Primary Prevention of Ischemic Stroke

Completed NA Last updated 22 July 2020

What this trial tests

NA trial testing oral appliance treatment in Sleep Apnea Syndromes in 100 participants. Completed in 31 December 2019.

Timeline

9 July 2016

Primary endpoint
1 September 2018

31 December 2019

Quick facts

Lead sponsor	Xuanwu Hospital, Beijing
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	100
Start date	9 July 2016
Primary completion	1 September 2018
Estimated completion	31 December 2019

Drugs / interventions tested

oral appliance treatment

Conditions studied

Sleep Apnea Syndromes — all drugs for Sleep Apnea Syndromes →
Atherosclerosis — all drugs for Atherosclerosis →
Carotid Plaque — all drugs for Carotid Plaque →

Sponsor

Xuanwu Hospital, Beijing

Who can join

Eligibility, any sex, with Sleep Apnea Syndromes or Atherosclerosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

1. The purpose of this study is to detect the differences of carotid atherosclerosis severity between patients with or without OSAHS(Obstructive Sleep Apnea and Hypopnea Syndrome) in a cross-sectional study in a large sample. 2. Then a longitudinal control study is conducted to observe the progress of the carotid atherosclerosis by vascular ultrasonography and the occurrence of cerebrovascular events after the intervention of the oral appliance for treating OSAHS，and finally explore the feasibility of using oral appliance to treat OSAHS in primary prevention of ischemic stroke.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Impact of mandibular advancement device therapy on cerebrovascular reactivity in patients with carotid atherosclerosis combined with OSAHS.
Qin L, Li N, Tong J, Hao Z, et al · · 2021 · cited 4× · PMID 33415656 · DOI 10.1007/s11325-020-02230-x
The differences of carotid atherosclerosis among non-OSAHS and OSAHS patients of different severities: a cross-sectional study.
Hao Z, Qin L, Tong J, Li N, et al · · 2021 · cited 1× · PMID 32720016 · DOI 10.1007/s11325-020-02145-7

Verify or expand the search:

Other recruiting trials for Sleep Apnea Syndromes

Currently open trials in the same condition.

NCT06578390 — Efficacy Investigation of the Medical Device Apneal® on Smartphone for Sleep Apnea-Hypopnea Syndrome Diagnosis · NA · recruiting
NCT07086599 — Typological Study of Sleep Pathologies During Psoriatic Rheumatism and SAPHO Syndrome: Prospective Study Within the Pari · recruiting
NCT04399200 — Apnea, Stroke and Incident Cardiovascular Events · recruiting
NCT04234828 — Validation of Withings Sleep for the Detection of Sleep Apnea Syndrome · active not recruiting

Other Xuanwu Hospital, Beijing trials

Trials by the same sponsor.

NCT07095933 — The Safety and Efficacy Evaluation of Everolimus as an Adjunctive Treatment for Focal Refractory Epilepsy · EARLY_PHASE1 · recruiting
NCT07519044 — Safety and Efficacy of Adjunctive GM1 to Mechanical Thrombectomy for Acute Anterior Circulation Large Vessel Occlusion · Phase 4 · not yet recruiting
NCT07396077 — Pre-operative Risk Assessment Combined With Targeted Intervention in the Chinese Elderly With Spine Surgery II · NA · not yet recruiting
NCT07457125 — The Effect of CB-Exo-A600 in Mild to Moderate Alzheimer's Disease · Phase 1, PHASE2 · not yet recruiting
NCT07479446 — Oliceridine Versus Sufentanil for Postoperative Nausea in Cerebellopontine Angle Surgery · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03665818 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Xuanwu Hospital, Beijing
Last refreshed: 22 July 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03665818.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing