NCT03664934

Pathophysiological Mechanism Behind Prolonged Whiplash Associated Disorders

Completed NA Last updated 3 October 2023

What this trial tests

NA trial testing Exercises in Whiplash Injuries in 60 participants. Completed in 16 December 2021.

Timeline

4 October 2018

Primary endpoint
16 December 2021

16 December 2021

Quick facts

Lead sponsor	Linkoeping University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	single
Primary purpose	diagnostic
Enrollment	60
Start date	4 October 2018
Primary completion	16 December 2021
Estimated completion	16 December 2021
Sites	1 location across Sweden

Drugs / interventions tested

• Exercises

Conditions studied

• Whiplash Injuries — all drugs for Whiplash Injuries →

Sponsor

Linkoeping University

Who can join

Adults 18 to 63, any sex, with Whiplash Injuries. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The knowledge of pathophysiological mechanisms behind prolonged Whiplash Associated Disorders (WAD) is insufficient and whether changes can be restored by rehabilitation or not is unknown. The aim of these studies are to investigate different parameters to further learn about pathophysiological mechanisms (neck muscle fatty infiltration, cross-sectional area, volume, inflammation and function, brain structure and activity, biomarkers for stress and inflammation, cervical kinaesthesia and balance before and after intervention) and the association for clinical outcomes in individuals with chronic WAD (n=30) compared with age and gender matched healthy individuals (n=30). Measurements will be made at baseline (patients and healthy) and at 3 months (patients only, at the end of treatment). However, for the blood and saliva samples, they will be re-investigated in the healthy group as well. The study results may contribute to the development of improved understanding and diagnostics in chronic WAD that may improve future rehabilitation.

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

1. Pathophysiology behind prolonged whiplash associated disorders: study protocol for an experimental study.
   Peolsson A, Karlsson A, Ghafouri B, Ebbers T, et al · · 2019 · cited 8× · PMID 30711003 · DOI 10.1186/s12891-019-2433-3
2. Neck muscle function improves after neck exercises in individuals with whiplash-associated disorders: a case-control ultrasound study with speckle-tracking analyses.
   Peterson G, Nilsson D, Jönsson M, Bennett K, et al · · 2024 · cited 3× · PMID 39138247 · DOI 10.1038/s41598-024-69136-6
3. The effect of a neck-specific exercise program on cervical kinesthesia for patients with chronic whiplash-associated disorders: a case-control study.
   Ragnarsdottir H, Peterson G, Gislason MK, Oddsdottir GL, et al · · 2024 · cited 2× · PMID 38693515 · DOI 10.1186/s12891-024-07427-9
4. Effect of neck-specific exercises on trapezius muscle function in chronic whiplash-associated disorders: a longitudinal case-control study using ultrasound and speckle-tracking analyses.
   Peterson G, Andersson E, Jönsson M, Peolsson A. · · 2026 · PMID 41741477 · DOI 10.1038/s41598-026-35963-y
5. Results of neck-specific exercise for altered postural sway in individuals with chronic whiplash-associated disorders: a longitudinal case-control study.
   Peolsson A, Bahat HS, German D, Peterson G. · · 2024 · PMID 38956135 · DOI 10.1038/s41598-024-66176-w
6. Altered neck muscles function during cervical rotation in chronic whiplash-associated disorders improved after neck-specific exercises: a real-time ultrasound case-control study
   Peterson G, Nilsson D, Jönsson M, Bennett K, et al · · 2023 · DOI 10.21203/rs.3.rs-3159780/v1