NCT03663556 (FEEDMI) is a clinical trial of Infant-feeding in Very Preterm Infants, sponsored by Universidade do Porto.

Who is sponsoring NCT03663556?

NCT03663556 is sponsored by Universidade do Porto.

What drugs are being tested in NCT03663556?

Interventions in NCT03663556: Infant-feeding.

What condition does NCT03663556 study?

NCT03663556 studies Very Preterm Infants.

Is NCT03663556 still recruiting?

NCT03663556 is currently status unknown. Last updated 2 October 2018.

Last reviewed 2018-10-02 · How we verify

NCT03663556: FEEDMI

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Feeding the Preterm Gut Microbiota - Impact of Infant-feeding on Preterm Gut Microbiota Development

Status unknown Last updated 2 October 2018

What this trial tests

trial testing Infant-feeding in Very Preterm Infants in 60 participants. Status unknown.

Timeline

25 May 2017

Primary endpoint
30 December 2018

30 December 2018

Quick facts

Lead sponsor	Universidade do Porto
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	60
Start date	25 May 2017
Primary completion	30 December 2018
Estimated completion	30 December 2018
Sites	2 locations across Portugal

Drugs / interventions tested

Infant-feeding

Conditions studied

Very Preterm Infants — all drugs for Very Preterm Infants →

Sponsor

Universidade do Porto — full company profile →

Who can join

Under 2 Days, any sex, with Very Preterm Infants. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Preterm infants are especially vulnerable to gut microbiota disruption and dysbiosis since their early gut microbiota is less abundant and diverse. Several factors may influence infants' microbiota such as mother's diet, mode of delivery, antibiotic exposure and type of feeding. The main goal of this observational study is to evaluate the impact of different types of feeding (breast milk, donor human milk and preterm formulas) on the intestinal microbiota of preterm infants hospitalized in the neonatal intensive care unit (NICU) of Maternidade Alfredo da Costa (MAC). Furthermore, the influence of mode of delivery and the mother's diet, among others factors, on vertical microbiota transmission will be evaluated. After delivery, mothers will be asked to collect their own fecal samples and will be invited to complete a semi-quantitative food frequency questionnaire. Stool samples will be collected from premature infants every 7 days. DNA will be extracted from fecal samples and different bacterial genus and species will be analyzed.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Extremely preterm neonates have more <i>Lactobacillus</i> in meconium than very preterm neonates - the <i>in utero</i> microbial colonization hypothesis.
Morais J, Marques C, Teixeira D, Durão C, et al · · 2020 · cited 15× · PMID 32658601 · DOI 10.1080/19490976.2020.1785804
Influence of Human Milk on Very Preterms' Gut Microbiota and Alkaline Phosphatase Activity.
Morais J, Marques C, Faria A, Teixeira D, et al · · 2021 · cited 14× · PMID 34066473 · DOI 10.3390/nu13051564

Verify or expand the search:

Other recruiting trials for Very Preterm Infants

Currently open trials in the same condition.

NCT06219525 — Higher and Standard Doses of Enteral Zinc Supplementation in Very Preterm Infants · NA · recruiting

Other Universidade do Porto trials

Trials by the same sponsor.

NCT07457697 — MyGENESIS: A Digital Psychoeducational Program for Donor-Conceived Young Adults · NA · not yet recruiting
NCT07503990 — Effects of Food Intake Sequence on Substrate Utilisation and Endurance Performance · NA · recruiting
NCT07436091 — Porcine Derma for Soft Tissue Augmentation Around Implants · NA · not yet recruiting
NCT07498556 — Immediate Restoration of a New Implant With High Primary Stability · NA · not yet recruiting
NCT07448870 — Evaluating the Mentalization-based Treatment Lighthouse Parenting Programme: Protocol of a Feasibility and Acceptability · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03663556 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Universidade do Porto
Last refreshed: 2 October 2018

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03663556.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing