Who is sponsoring PERT?

PERT is sponsored by University of Pennsylvania.

What condition does PERT study?

PERT studies Ischemia Reperfusion Injury.

What drugs are being tested in PERT?

Interventions: Conjugated Estrogen, Normal saline.

What is the status of PERT?

PERT is currently ACTIVE_NOT_RECRUITING.

Last reviewed 2026-04-16 · How we verify

Intravenous Estrogen in Kidney Transplant Study (PERT)

NCT03663543 PHASE1, PHASE2 ACTIVE_NOT_RECRUITING

Ischemia perfusion injury (IRI) is a major cause of organ injury during kidney transplantation. Currently there are no treatments for IRI other than dialysis. Preliminary studies in female mice have found protection from IRI when given short term estrogen supplements. This study will look at the effect of intravenous estrogen given peri-operatively to reduce the effect of IRI in female kidney transplant recipients.

Details

Lead sponsor	University of Pennsylvania
Phase	PHASE1, PHASE2
Status	ACTIVE_NOT_RECRUITING
Enrolment	30
Start date	Fri Aug 26 2016 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Sat May 01 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

Ischemia Reperfusion Injury

Interventions

Conjugated Estrogen
Normal saline

Countries

United States