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NCT03661216
Evaluation of Nephure™, and the Reduction of Dietary Oxalate, in Healthy Volunteers
NA trial testing Nephure Oxalate-reducing Enzyme in Healthy in 33 participants. Completed in 5 August 2018.
5 August 2018
Quick facts
| Lead sponsor | Captozyme, Inc. |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | quadruple |
| Primary purpose | other |
| Enrollment | 33 |
| Start date | 11 July 2018 |
| Primary completion | 5 August 2018 |
| Estimated completion | 5 August 2018 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Nephure Oxalate-reducing Enzyme
- Placebo
Conditions studied
- Healthy — all drugs for Healthy →
Sponsor
Captozyme, Inc.
Who can join
Adults 18 to 55, any sex, with Healthy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this double-blind study is to determine the effect of reducing oxalates in the diet of healthy volunteers by using Nephure, an oxalate-reducing enzyme, as compared to placebo.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
A Prospective, Double-Blind, Randomized, Placebo-Controlled, Crossover Study Using an Orally Administered Oxalate Decarboxylase (OxDC).
Quintero E, Bird VY, Liu H, Stevens G, et al · · 2020 · cited 14× · PMID 35372879 · DOI 10.34067/kid.0001522020 -
Future treatments for hyperoxaluria.
Burns Z, Knight J, Fargue S, Holmes R, et al · · 2020 · cited 14× · PMID 31895888 · DOI 10.1097/mou.0000000000000709 -
Antioxidant and Cytotoxic Effects and Identification of <i>Ophiocordyceps sinensis</i> Bioactive Proteins Using Shotgun Proteomic Analysis.
Kong BH, Yap CA, Razif MFM, Ng ST, et al · · 2021 · cited 10× · PMID 34316281 · DOI 10.17113/ftb.59.02.21.7151
Verify or expand the search:
- PubMed search for NCT03661216
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03661216 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Captozyme, Inc.
- Last refreshed: 19 September 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03661216.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing