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NCT03654573: MOCA
The MOCA I Study - Microvascular Obstruction with CoFI™ System Assessment
Phase 1 trial testing CorFlow Controlled Flow Infusion System - CoFI™ in STEMI - ST Elevation Myocardial Infarction in 73 participants. Completed in 18 December 2024.
18 December 2024
Quick facts
| Lead sponsor | CorFlow Therapeutics AG |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | other |
| Enrollment | 73 |
| Start date | 4 June 2019 |
| Primary completion | 18 December 2024 |
| Estimated completion | 18 December 2024 |
| Sites | 8 locations across Switzerland, United Kingdom, Lithuania |
Drugs / interventions tested
- CorFlow Controlled Flow Infusion System - CoFI™
Conditions studied
- STEMI - ST Elevation Myocardial Infarction — all drugs for STEMI - ST Elevation Myocardial Infarction →
- Microvascular Obstruction — all drugs for Microvascular Obstruction →
Sponsor
CorFlow Therapeutics AG
Who can join
18 and older, any sex, with STEMI - ST Elevation Myocardial Infarction or Microvascular Obstruction. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
First-in-Human study to assess the CoFI™ device related safety and the feasibility of the diagnostic and the therapeutic sequence as well as the correlation between the dynamic microvascular resistance (dMVR) and microvascular obstruction (MVO) as measured by MRI in patients presenting with acute ST-elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Treatment and Care of Patients with ST-Segment Elevation Myocardial Infarction-What Challenges Remain after Three Decades of Primary Percutaneous Coronary Intervention?
Zuccarelli V, Andreaggi S, Walsh JL, Kotronias RA, et al · · 2024 · cited 7× · PMID 38792463 · DOI 10.3390/jcm13102923
Verify or expand the search:
- PubMed search for NCT03654573
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of CorFlow Controlled Flow Infusion System - CoFI™
Trials testing the same drug.
- NCT06909578 — Microvascular Obstruction Diagnosis Using the CoFI™ System Assessment - II · NA · not yet recruiting
Other recruiting trials for STEMI - ST Elevation Myocardial Infarction
Currently open trials in the same condition.
- NCT07160491 — Early Thrombolysis Guided by AI-Assisted App in Patients With STEMI · NA · recruiting
- NCT06013020 — Century Clot-Guided Prophylactic Rivaroxaban for Post STEMI Complicating Left Ventricular Thrombus · Phase 4 · recruiting
- NCT06384846 — AI Algorithms in Prediction of ACS Based on Leukocyte Properties · recruiting
- NCT04436978 — What is the Optimal Antithrombotic Strategy in Patients With Atrial Fibrillation Undergoing PCI? · Phase 4 · recruiting
- NCT05800951 — Can Escalation Reduce Acute Myocardial Infarction Mortality in Cardiogenic Shock · active not recruiting
Other CorFlow Therapeutics AG trials
Trials by the same sponsor.
- NCT06909578 — Microvascular Obstruction Diagnosis Using the CoFI™ System Assessment - II · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03654573 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by CorFlow Therapeutics AG
- Last refreshed: 19 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03654573.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing