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NCT03652519: TRAINUVIMAB
High-intensity Training and Its Effects on Neuroplasticity
NA trial testing Exercise Training in Multiple Sclerosis in 72 participants. Completed in 11 November 2019.
11 November 2019
Quick facts
| Lead sponsor | Klinik Valens |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | supportive care |
| Enrollment | 72 |
| Start date | 21 November 2018 |
| Primary completion | 11 November 2019 |
| Estimated completion | 11 November 2019 |
| Sites | 1 location across Switzerland |
Drugs / interventions tested
- Exercise Training
Conditions studied
- Multiple Sclerosis — all drugs for Multiple Sclerosis →
Sponsor
Klinik Valens
Who can join
21 and older, any sex, with Multiple Sclerosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Regular physical activity is known to reduce the risk for some neurodegenerative disorders and their symptoms. Several studies have shown positive effects of therapeutic exercise interventions on motor- and cognitive function as well as psychosocial benefits in persons with multiple sclerosis (MS). To improve exercise recommendations, it is necessary to learn more about the underlying biological mechanisms. A reduction of inflammatory stress through physical exercise has been suspected as one key mechanism, mediating the positive effects of exercise in the context of MS (being a "classical" neuro-inflammatory disease). This randomized controlled trial aims to investigate the influence of two different rehabilitative endurance exercise programs (3x/week moderate vs. vigorous endurance exercise) on (1) (anti-)inflammatory immune signalling and (2) various aspects of participation.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Exercise Diminishes Plasma Neurofilament Light Chain and Reroutes the Kynurenine Pathway in Multiple Sclerosis.
Joisten N, Rademacher A, Warnke C, Proschinger S, et al · · 2021 · cited 54× · PMID 33782190 · DOI 10.1212/nxi.0000000000000982 -
Influence of different rehabilitative aerobic exercise programs on (anti-) inflammatory immune signalling, cognitive and functional capacity in persons with MS - study protocol of a randomized controlled trial.
Joisten N, Rademacher A, Bloch W, Schenk A, et al · · 2019 · cited 16× · PMID 30849952 · DOI 10.1186/s12883-019-1267-9 -
Cognitive Impairment Impacts Exercise Effects on Cognition in Multiple Sclerosis.
Rademacher A, Joisten N, Proschinger S, Bloch W, et al · · 2020 · cited 6× · PMID 33633658 · DOI 10.3389/fneur.2020.619500
Verify or expand the search:
- PubMed search for NCT03652519
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Exercise Training
Trials testing the same drug.
- NCT07384039 — Exercise Training in Patients With Myeloproliferative Neoplasms · NA · not yet recruiting
- NCT07439224 — Qigong and Multicomponent Exercise in Panic Disorder · NA · recruiting
- NCT06627296 — The Effect of Combined Exercise and NMES on Strength, Proprioception and Reaction Time in Scapholunate Instability · NA · completed
- NCT05797857 — Exercise Training in Transthyretin Cardiac Amyloidosis · NA · recruiting
- NCT06322030 — Weight Loss and ExeRcise for Post-stroke Veterans · NA · recruiting
Other recruiting trials for Multiple Sclerosis
Currently open trials in the same condition.
- NCT07507084 — The Effect of Internal- or External-Focused Exercise Training, Administered in Conjunction With a Cognitive Task, on Wal · NA · recruiting
- NCT07524231 — Evaluation of the Effects of Laughter Yoga · NA · recruiting
- NCT07489794 — URINARY INCONTINENCE AND PELVIC FLOOR MUSCLE ACTIVITY IN MULTIPLE SCLEROSIS · recruiting
- NCT07236684 — Identification of Factors Related to UI in Patients With MS and EMG Assessment of PFM Activity · recruiting
- NCT07500727 — Skeletal Muscle Aging and Responsiveness in Aged People With MS · NA · recruiting
Other Klinik Valens trials
Trials by the same sponsor.
- NCT05562414 — Transient and Immediate Motor Effects of Exercise in Progressive Multiple Sclerosis · NA · unknown
- NCT05229861 — The Influence of HIIT Versus MCT on Cardiorespiratory Fitness in PPMS · NA · unknown
- NCT04896905 — Rehabilitation After Covid19-Clinical Results and Predictive Factors · completed
- NCT04356248 — Training and Energy Management Education to Improve Quality of Life in Persons With Multiple Sclerosis · NA · completed
- NCT06307210 — Is Inpatient Rehabilitation Effective for Very Old Patients? · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03652519 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Klinik Valens
- Last refreshed: 13 November 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03652519.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing