NCT03651934

Verification of Correlation Between Genetic Testing of Nutritional Metabolism and Clinical Biochemical Indicators

Status unknown NA Last updated 29 August 2018

What this trial tests

NA trial testing Normal iron in Pregnant Women in 600 participants. Status unknown.

Timeline

1 October 2018

Primary endpoint
10 September 2019

1 June 2020

Quick facts

Lead sponsor	Peking Union Medical College Hospital
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	600
Start date	1 October 2018
Primary completion	10 September 2019
Estimated completion	1 June 2020

Drugs / interventions tested

• Normal iron
• Weak iron
• Normal selenium
• Weak selenium

Conditions studied

• Pregnant Women — all drugs for Pregnant Women →

Sponsor

Peking Union Medical College Hospital

Who can join

Eligibility, female only, with Pregnant Women. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The research plan is divided into two parts. The first part is the correlation study .It is planned to include women who prepare for pregnancy or in the early stages of pregnancy to carry out the detection of 25 loci SNP of 21 genes of 9 nutrients, to predict the nutritional abnormalities of 9 nutrients, and to determine the nutritional status of 9 nutrients, and then verify the correlation between nutrient metabolism related gene SNP and nutrient nutrition status .The second part selects iron and selenium which are commonly lacking in Chinese women of childbearing age. A intervention study is designed for these two nutrients. According to the SNP grouping of related gene loci, observe the effect of nutrition intervention and explore the nutrition intervention strategies of different SNP individuals.

Publications & conference data

7 peer-reviewed publications reference this trial (live from Europe PMC):

1. Associations Between Gestational Diabetes Mellitus Risk and Folate Status in Early Pregnancy and <i>MTHFR</i> C677T Polymorphisms in Chinese Women.
   Liu PJ, Liu Y, Ma L, Yao AM, et al · · 2020 · cited 30× · PMID 32440179 · DOI 10.2147/dmso.s250279
2. The relationship between plasma taurine levels in early pregnancy and later gestational diabetes mellitus risk in Chinese pregnant women.
   Liu PJ, Liu Y, Ma L, Liu L, et al · · 2021 · cited 7× · PMID 33846497 · DOI 10.1038/s41598-021-87178-y
3. Metabolic profiling in early pregnancy and associated factors of folate supplementation: A cross-sectional study.
   Zhao R, An Z, Sun Y, Xia L, et al · · 2021 · cited 6× · PMID 34455263 · DOI 10.1016/j.clnu.2021.01.012
4. Targeted metabolomics profiling in pregnancy associated with vitamin D deficiency.
   Li X, An Z, Yao A, Li R, et al · · 2024 · cited 5× · PMID 38643102 · DOI 10.1186/s12884-024-06454-7
5. UHPLC-MS/MS-Based Metabolomics and Clinical Phenotypes Analysis Reveal Broad-Scale Perturbations in Early Pregnancy Related to Gestational Diabetes Mellitus.
   Hu T, An Z, Li H, Liu Y, et al · · 2022 · cited 5× · PMID 36061360 · DOI 10.1155/2022/4231031
6. Potential Serum Biomarkers Associated with Premature Rupture of Fetal Membranes in the First Trimester.
   An Z, Zhao R, Han F, Sun Y, et al · · 2022 · cited 3× · PMID 35873552 · DOI 10.3389/fphar.2022.915935
7. The Association Between the Imbalance of Single-Carbon Nutrients in Early Pregnancy and Gestational Diabetes Mellitus Risk is Influenced by Serum Selenium Status: A Cohort Study.
   Liu PJ, Ma L, Li R, Liu Y. · · 2023 · cited 1× · PMID 37881350 · DOI 10.2147/dmso.s428286