NCT03651817 is a NA clinical trial of Mechanical ventilation in Lung Injury, Acute, sponsored by Kocaeli University.

Who is sponsoring NCT03651817?

NCT03651817 is sponsored by Kocaeli University.

What drugs are being tested in NCT03651817?

Interventions in NCT03651817: Mechanical ventilation.

What condition does NCT03651817 study?

NCT03651817 studies Lung Injury, Acute, Ventilator-Induced Lung Injury, Ventilator Adverse Event.

Is NCT03651817 still recruiting?

NCT03651817 is currently completed. Last updated 5 March 2020.

Last reviewed 2020-03-05 · How we verify

NCT03651817

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Lung Protection Strategy in Open Heart Surgery: Which Tidal Volume is Better 8ml/kg or 6ml/kg

Completed NA Last updated 5 March 2020

What this trial tests

NA trial testing Mechanical ventilation in Lung Injury, Acute in 32 participants. Completed in 21 November 2019.

Timeline

15 October 2018

Primary endpoint
20 November 2019

21 November 2019

Quick facts

Lead sponsor	Kocaeli University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	prevention
Enrollment	32
Start date	15 October 2018
Primary completion	20 November 2019
Estimated completion	21 November 2019
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

Mechanical ventilation

Conditions studied

Lung Injury, Acute — all drugs for Lung Injury, Acute →
Ventilator-Induced Lung Injury — all drugs for Ventilator-Induced Lung Injury →
Ventilator Adverse Event — all drugs for Ventilator Adverse Event →

Sponsor

Kocaeli University

Who can join

Adults 18 to 75, any sex, with Lung Injury, Acute or Ventilator-Induced Lung Injury. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Respiratory complications range from 8% to 79% of the frequency after open heart surgery where the patient is on-pump operated by cardiopulmonary machine. There were many changes in physiology due to anesthesia and cardiac surgery which cause volume and barotrauma complications with mechanical ventilation. These complications increase cost by prolonging morbidity and morbidity as well as hospital stay. Intraoperative and postoperative mechanical ventilation strategies can prevent these complications. CPB stimulates the systemic inflammatory response to the secretion of neutrophil, endotoxin and proinflammatory cytokines in the complex, increasing the permeability of the capillaries. Although coronary artery bypass graft surgery (CABG) is associated with a 0.4% to 2.0% acute respiratory distress syndrome (ARDS), mortality is quite high. Lung-protective ventilation strategies commonly used for prevention of ARDS. Ferrando et al. have proposed pulmonary ventilation with a tidal volume (TV) of less than 10 mL / kg as a pulmonary intraoperative protective ventilation strategy. Investigators aimed to compare oxygenation and ventilation parameters with respiratory mechanics in patients who underwent open heart surgery and were ventilated with 6 ml / kg tidal volume and 8 ml / kg TV, which were recommended as lung protective ventilation strategies during anesthesia.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other trials of Mechanical ventilation

Trials testing the same drug.

NCT06087939 — Outcome and Predictors of Mortality of Patients on Prolonged Mechanical Ventilation · not yet recruiting
NCT06480162 — Mechanical Ventilation on Hippocampus · recruiting
NCT06316063 — Hemodynamic Effects of Apnoeic Oxygenation With High-flow Nasal Oxygen in Adults Undergoing Laryngeal Surgery · NA · completed
NCT05853068 — Assessment of PaO2/FiO2 Ratio Pre and POst INTubation · active not recruiting
NCT06425354 — Use of 'Mechanical Power' as a Predictor of Increased Serum and Pulmonary Proinflammatory Cytokine Concentrations in Pat · recruiting

Other recruiting trials for Lung Injury, Acute

Currently open trials in the same condition.

NCT04289324 — Open Lung Maneuvers During High Frequency Oscillatory Ventilation in Preterm Infants · NA · recruiting

Other Kocaeli University trials

Trials by the same sponsor.

NCT06737887 — The Effect of Preoperative Stoma Simulation on Anxiety and Postoperative Adaptation · NA · recruiting
NCT07483593 — Baseline Gastric Volume in Diabetic vs Non-Diabetic Patients · not yet recruiting
NCT07536659 — Evaluation of Serum Autophagic Biomarkers in the Acute Response to Walking and Cycling in Healthy Male Individuals · enrolling by invitation
NCT07482696 — Electromyographic Biofeedback Therapy in Patients With Dyssynergic Defecation · NA · not yet recruiting
NCT07497945 — Optic Nerve Sheath Diameter for Predicting Post-Dural Puncture Headache in Cesarean Section Patients · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03651817 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Kocaeli University
Last refreshed: 5 March 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03651817.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing