Who is sponsoring NCT03648463?

NCT03648463 is sponsored by Stanford University.

What drugs are being tested in NCT03648463?

Interventions in NCT03648463: arthroscopy of the affected knee/ Bone Marrow Concentrate Injection.

What condition does NCT03648463 study?

NCT03648463 studies Cartilage Degeneration, Rotator Cuff Tear, Osteoarthritis, Knee.

Is NCT03648463 still recruiting?

NCT03648463 is currently withdrawn. Last updated 29 August 2022.

Last reviewed 2022-08-29 · How we verify

NCT03648463

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Use of MRI Labeling Technique to Track Mesenchymal Stem Cell Survival in Orthopaedic Conditions

Withdrawn NA Last updated 29 August 2022

What this trial tests

NA trial testing arthroscopy of the affected knee/ Bone Marrow Concentrate Injection in Cartilage Degeneration. Withdrawn.

Timeline

1 October 2019

Primary endpoint
31 December 2020

31 December 2020

Quick facts

Lead sponsor	Stanford University
Phase	NA
Status	Withdrawn
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Start date	1 October 2019
Primary completion	31 December 2020
Estimated completion	31 December 2020

Drugs / interventions tested

arthroscopy of the affected knee/ Bone Marrow Concentrate Injection

Conditions studied

Cartilage Degeneration — all drugs for Cartilage Degeneration →
Rotator Cuff Tear — all drugs for Rotator Cuff Tear →
Osteoarthritis, Knee — all drugs for Osteoarthritis, Knee →

Sponsor

Stanford University

Who can join

Adults 30 to 70, any sex, with Cartilage Degeneration or Rotator Cuff Tear. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The primary objective is to determine whether a surgical intervention involving removing of the calcified cartilage cap in patients with Grade II Kellgren-Lawrence osteoarthritis influences the incorporation of labeled bone marrow aspirate concentrate (BMAC)-derived cells within the cartilage regenerate vs labeled BMAC cells delivered after arthroscopy without removing of the calcified cartilaginous layer. The survival and incorporation of the BMAC labeled cells will be evaluated with MRI using the Ferumoxytol infusion stem cell labeling technique. The second arm of the study evaluating cell fate after injecting stem cells under a rotator cuff repair will also be explored. The secondary objectives are to 1) determine which surgical intervention leads to better clinical outcomes as measured by Knee Injury and Osteoarthritis Outcome Score (KOOS) at 12 months, and 2) determine who long we can track the labeled-BMAC cells in the knee.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Recent advances of biomaterials in stem cell therapies.
Xue Y, Baig R, Dong Y. · · 2022 · cited 9× · PMID 34933291 · DOI 10.1088/1361-6528/ac4520

Verify or expand the search:

Other recruiting trials for Cartilage Degeneration

Currently open trials in the same condition.

NCT06368544 — Effect of Early Gait Training on Knee Cartilage Degeneration After Anterior Cruciate Ligament Reconstruction · NA · recruiting
NCT06249906 — Efficacy of Bioceramic Materials for Bone Defects Repair · NA · recruiting
NCT06612372 — Effects of 60-day-6° Head-down Bed Rest on Cartilage and Function of the Knee Joint · NA · recruiting
NCT04536103 — Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry · recruiting

Other Stanford University trials

Trials by the same sponsor.

NCT05945147 — Ketamine and Midazolam Infusions for CRPS: Feasibility Study · Phase 2 · withdrawn
NCT04225949 — Patients Understanding of PROM Graphs · NA · withdrawn
NCT06273098 — School-Based Bladder Health Intervention · NA · withdrawn
NCT04652635 — Management of Nailbed Injuries · NA · withdrawn
NCT05443503 — Stanford Spine Keeper - Managing Your Low Back Pain · NA · suspended

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03648463 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Stanford University
Last refreshed: 29 August 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03648463.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing