Last reviewed · How we verify
NCT03646747
Oxygen Enhanced MRI Measurement in Head and Neck Cancer: Validation and Efficacy of Response.
NA trial testing MRI scan in Head and Neck Cancer in 40 participants. Status unknown.
31 December 2021
Quick facts
| Lead sponsor | Sally Falk |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 40 |
| Start date | 1 September 2018 |
| Primary completion | 31 December 2021 |
| Estimated completion | 31 December 2021 |
Drugs / interventions tested
- MRI scan
Conditions studied
- Head and Neck Cancer — all drugs for Head and Neck Cancer →
Sponsor
Sally Falk
Who can join
18 and older, any sex, with Head and Neck Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a prospective pilot study to investigate the potential clinical value of oxygen-enhanced magnetic resonance (OE-MRI) biomarkers in head and neck radiotherapy.
Publications & conference data
5 peer-reviewed publications reference this trial (live from Europe PMC):
-
Perspectives on Hypoxia Signaling in Tumor Stroma.
Zhang Y, Coleman M, Brekken RA. · · 2021 · cited 28× · PMID 34202979 · DOI 10.3390/cancers13123070 -
Rationale for hypoxia assessment and amelioration for precision therapy and immunotherapy studies.
Dewhirst MW, Mowery YM, Mitchell JB, Cherukuri MK, et al · · 2019 · cited 28× · PMID 30614815 · DOI 10.1172/jci126044 -
Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer.
Dubec MJ, Price J, Berks M, Gaffney J, et al · · 2024 · cited 6× · PMID 39142654 · DOI 10.1158/1078-0432.ccr-24-1170 -
Imaging hypoxia for head and neck cancer: current status, challenges, and prospects.
Huang W, Li N, Zhu S, Zhang Y, et al · · 2025 · PMID 40860130 · DOI 10.7150/thno.112781 -
Translation of dynamic contrast-enhanced imaging onto a magnetic resonance-guided linear accelerator in patients with head and neck cancer.
Dubec MJ, Berks M, Price J, McDaid L, et al · · 2025 · PMID 39802650 · DOI 10.1016/j.phro.2024.100689
Verify or expand the search:
- PubMed search for NCT03646747
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Currently open trials in the same condition.
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Other Sally Falk trials
Trials by the same sponsor.
- NCT02068378 — Visual Feedback With Optical Sensing - A Feasibility Study · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03646747 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Sally Falk
- Last refreshed: 24 August 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03646747.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing