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NCT03646747

Oxygen Enhanced MRI Measurement in Head and Neck Cancer: Validation and Efficacy of Response.

Status unknown NA Last updated 24 August 2018
What this trial tests

NA trial testing MRI scan in Head and Neck Cancer in 40 participants. Status unknown.

Timeline
1 September 2018
Primary endpoint
31 December 2021
31 December 2021

Quick facts

Lead sponsorSally Falk
PhaseNA
StatusStatus unknown
Study typeINTERVENTIONAL
Allocationna
Designsingle group
Maskingnone
Primary purposebasic science
Enrollment40
Start date1 September 2018
Primary completion31 December 2021
Estimated completion31 December 2021

Drugs / interventions tested

Conditions studied

Sponsor

Sally Falk

Who can join

18 and older, any sex, with Head and Neck Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a prospective pilot study to investigate the potential clinical value of oxygen-enhanced magnetic resonance (OE-MRI) biomarkers in head and neck radiotherapy.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Perspectives on Hypoxia Signaling in Tumor Stroma.
    Zhang Y, Coleman M, Brekken RA. · · 2021 · cited 28× · PMID 34202979 · DOI 10.3390/cancers13123070
  2. Rationale for hypoxia assessment and amelioration for precision therapy and immunotherapy studies.
    Dewhirst MW, Mowery YM, Mitchell JB, Cherukuri MK, et al · · 2019 · cited 28× · PMID 30614815 · DOI 10.1172/jci126044
  3. Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer.
    Dubec MJ, Price J, Berks M, Gaffney J, et al · · 2024 · cited 6× · PMID 39142654 · DOI 10.1158/1078-0432.ccr-24-1170
  4. Imaging hypoxia for head and neck cancer: current status, challenges, and prospects.
    Huang W, Li N, Zhu S, Zhang Y, et al · · 2025 · PMID 40860130 · DOI 10.7150/thno.112781
  5. Translation of dynamic contrast-enhanced imaging onto a magnetic resonance-guided linear accelerator in patients with head and neck cancer.
    Dubec MJ, Berks M, Price J, McDaid L, et al · · 2025 · PMID 39802650 · DOI 10.1016/j.phro.2024.100689

Verify or expand the search:

Other trials of MRI scan

Trials testing the same drug.

Other recruiting trials for Head and Neck Cancer

Currently open trials in the same condition.

Other Sally Falk trials

Trials by the same sponsor.

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Data sources for this page

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