Last reviewed · How we verify
NCT03641443: aICPTumor
non_invasive_aICP_Tumor
NA trial testing Non-invasive measurement of intracranial pressure in Tumor, Brain in 48 participants. Completed in 31 December 2019.
31 December 2019
Quick facts
| Lead sponsor | Kantonsspital Aarau |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 48 |
| Start date | 12 September 2016 |
| Primary completion | 31 December 2019 |
| Estimated completion | 31 December 2019 |
| Sites | 1 location across Switzerland |
Drugs / interventions tested
- Non-invasive measurement of intracranial pressure
Conditions studied
- Tumor, Brain — all drugs for Tumor, Brain →
- Intracranial Pressure Increase — all drugs for Intracranial Pressure Increase →
Sponsor
Kantonsspital Aarau — full company profile →
Who can join
18 and older, any sex, with Tumor, Brain or Intracranial Pressure Increase. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Since decades, neurosurgeons and neurooncologists assumed that the mass effect of brain tumors with peritumoral edema or intratumoral hemorrhage might lead to increased ICP. Therefore, decisions on surgical procedures and medical treatments were made based on clinical and radiological findings suggesting increased ICP. But in fact, no measurement has ever confirmed increased ICP in brain tumor patients. From an ethical point of view, it is not justifiable to implant an intraparenchymal ICP probe within an invasive surgical procedure in a brain tumor patient unless the patient is comatose or present with rapid impairment of the level of consciousness. Therefore, with the new medical device for non-invasive ICP measurement presented in this study protocol, we will be able to measure absolute ICP values in patients with brain tumors.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Changing the paradigm of intracranial hypertension in brain tumor patients: a study based on non-invasive ICP measurements.
Kienzler JC, Zakelis R, Marbacher S, Bäbler S, et al · · 2020 · cited 8× · PMID 32631262 · DOI 10.1186/s12883-020-01837-7
Verify or expand the search:
- PubMed search for NCT03641443
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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Other Kantonsspital Aarau trials
Trials by the same sponsor.
- NCT04700371 — Vessel Deformations and Restenosis After Stenting of the Popliteal Artery · NA · withdrawn
- NCT06637267 — Prospective Evaluation of Proclarix® Test to Improve Risk Stratification in Men Scheduled for MpMRI and Prostate Biopsy · recruiting
- NCT05504473 — Blink Restoration in Patients With Facial Nerve Palsy · NA · completed
- NCT04811794 — Young Survivors at Kantonsspital Aarau, Switzerland · recruiting
- NCT04709107 — Validation of the VascuQoL-6 Questionnaire to Assess ePROM After Revascularization for Lower Limb Peripheral Arterial Di · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03641443 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Kantonsspital Aarau
- Last refreshed: 26 February 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03641443.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing