Who is sponsoring NCT03640689?

NCT03640689 is sponsored by National University of Ireland, Galway, Ireland.

What drugs are being tested in NCT03640689?

Interventions in NCT03640689: Endovenous ablation + iliac US +/- iliac stenting, Endovenous ablation of Great Saphenous Vein.

What condition does NCT03640689 study?

NCT03640689 studies Venous Leg Ulcer.

Is NCT03640689 still recruiting?

NCT03640689 is currently status unknown. Last updated 3 March 2021.

Last reviewed 2021-03-03 · How we verify

NCT03640689: Develop

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

DEep VEin Lesion OPtimisation (DEVELOP) Trial

Status unknown NA Last updated 3 March 2021

What this trial tests

NA trial testing Endovenous ablation + iliac US +/- iliac stenting in Venous Leg Ulcer in 60 participants. Status unknown.

Timeline

15 July 2019

Primary endpoint
1 September 2024

1 September 2024

Quick facts

Lead sponsor	National University of Ireland, Galway, Ireland
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	diagnostic
Enrollment	60
Start date	15 July 2019
Primary completion	1 September 2024
Estimated completion	1 September 2024
Sites	2 locations across Ireland

Drugs / interventions tested

Endovenous ablation + iliac US +/- iliac stenting
Endovenous ablation of Great Saphenous Vein

Conditions studied

Venous Leg Ulcer — all drugs for Venous Leg Ulcer →

Sponsor

National University of Ireland, Galway, Ireland

Who can join

18 and older, any sex, with Venous Leg Ulcer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a prospective, single centre, randomised controlled, feasibility study recruiting patients with lower limb venous ulceration and Great Saphenous incompetence. Patients will be randomised to undergo either truncal ablation and compression therapy or truncal ablation, simultaneous iliac interrogation with intravascular ultrasound and stenting of significant (\>50%) iliac vein lesions plus compression therapy. The primary endpoints will be ulcer healing and procedural safety. Secondary endpoints include time to healing, quality of life and clinical scores, ulcer recurrence rates and rates of post-thrombotic syndrome. Follow up will be over a five-year period. This feasibility study is designed to include 60 patients. Should it be practicable a total of 594 patients would be required to adequately power the study to definitively address ulcer-healing rates.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

DEep VEin Lesion OPtimisation (DEVELOP) trial: protocol for a randomised, assessor-blinded feasibility trial of iliac vein intervention for venous leg ulcers.
Aherne TM, Keohane C, Mullins M, Zafar AS, et al · · 2021 · cited 4× · PMID 33541436 · DOI 10.1186/s40814-021-00779-2
DEep VEin Lesion OPtimisation (DEVELOP) Trial. Protocol for a randomised, assessor-blinded feasibility trial of iliac vein intervention for venous leg ulcers
Aherne TM, Keohane C, Mullins M, Black SA, et al · · 2019 · DOI 10.21203/rs.2.314/v3

Verify or expand the search:

Other recruiting trials for Venous Leg Ulcer

Currently open trials in the same condition.

NCT07255937 — PMCF Study of Debridement Pad · NA · recruiting
NCT07046767 — CAMP RWE Trial: Amnion Grafts for Healing Hard-to-Heal Ulcers in RW Populations · NA · recruiting
NCT07211243 — Suprasorb®X+PHMB Pro vs Suprasorb®X+PHMB in Treatment of Infected Venous Leg Ulcers · NA · recruiting
NCT07061613 — Prospective Case Series Evaluating the Efficacy and Safety of NeoThelium FT for Venous Leg Ulcers · NA · recruiting
NCT06544564 — Human Amniotic Membrane On Venous Leg Ulcers In an Elderly Population · NA · recruiting

Other National University of Ireland, Galway, Ireland trials

Trials by the same sponsor.

NCT07477938 — A Single-Arm Interventional Trial of Pepper- Robot Delivered Cancer Education for Adults With Intellectual Disability · NA · not yet recruiting
NCT06147479 — Cognitive Stimulation in Daily Activities for People Living With Early to Middle Stage Dementia · NA · completed
NCT06212050 — Feasibility, Safety, and Effectiveness of the ACURATE neo2 Transcatheter Heart Valve for Severe Bicuspid Aortic Stenosis · enrolling by invitation
NCT05170100 — Evaluating a Digital Intervention for Overactive Bladder · NA · completed
NCT04471103 — Comparison of Multi-Round and Real-Time Delphi Survey Methods · NA · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03640689 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by National University of Ireland, Galway, Ireland
Last refreshed: 3 March 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03640689.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing