Last reviewed · How we verify
NCT03640234: RAVE
Return of Actionable Variants Empirical Study
trial in Familial Hypercholesterolemia in 418 participants. Completed in 1 September 2022.
1 September 2022
Quick facts
| Lead sponsor | Mayo Clinic |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 418 |
| Start date | 25 February 2016 |
| Primary completion | 1 September 2022 |
| Estimated completion | 1 September 2022 |
Conditions studied
- Familial Hypercholesterolemia — all drugs for Familial Hypercholesterolemia →
Sponsor
Mayo Clinic
Who can join
Adults 18 to 70, any sex, with Familial Hypercholesterolemia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a genomic implementation project with ancillary studies to understand the impact on patients' health and well-being of returning genomic results to them and depositing those results in the medical record.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
A pragmatic clinical trial of cascade testing for familial hypercholesterolemia.
Miller AA, Bangash H, Smith CY, Wood-Wentz CM, et al · · 2022 · cited 14× · PMID 36173399 · DOI 10.1016/j.gim.2022.08.026 -
Design of a Controlled Trial of Cascade Screening for Hypercholesterolemia: The (CASH) Study.
Kullo IJ, Bailey KR. · · 2018 · cited 8× · PMID 30142941 · DOI 10.3390/jpm8030027
Verify or expand the search:
- PubMed search for NCT03640234
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Familial Hypercholesterolemia
Currently open trials in the same condition.
- NCT07470723 — The ORIGIN-FH Study · NA · recruiting
- NCT06546137 — National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Un · recruiting
- NCT04529967 — Child-Parent Familial Hypercholesterolemia Screening · recruiting
- NCT06439654 — Atlantic Lipid Lowering Treatment Optimization Program · NA · recruiting
- NCT06458010 — Clinical Exploration Trial of YOLT-101 in the Treatment of Familial Hypercholesterolemia (FH) · EARLY_PHASE1 · recruiting
Other Mayo Clinic trials
Trials by the same sponsor.
- NCT07126548 — A Point of Prostate Cancer Diagnosis Virtual Reality Assistant Intervention in Supporting Newly Diagnosed Black Men · NA · not yet recruiting
- NCT07221656 — Evaluation of Prolonged Asparaginase Activity Levels After Calaspargase Pegol Administration · not yet recruiting
- NCT06891001 — The Utilization of a Shoe Insert on Individuals With Unilateral Greater Trochanteric Pain Syndrome on Single Leg Stance, · NA · not yet recruiting
- NCT07169799 — Impact of Cryotherapy Spray (Tru-Freeze) for the Eradication of Gastric Antral Vascular Ectasia (ICE-GAVE) · NA · recruiting
- NCT07086183 — Perioperative Risk in Patients on Chronic Aspirin Undergoing Craniotomy · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03640234 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mayo Clinic
- Last refreshed: 27 September 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03640234.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing