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NCT03631680: RESUME
The Role of Estrogen in Adipocyte Remodeling Following Surgical Menopause
trial testing Bilateral Oophorectomy Surgery in Menopause Surgical in 2 participants. Terminated before completion.
11 November 2022
Quick facts
| Lead sponsor | Pennington Biomedical Research Center |
|---|---|
| Status | Terminated |
| Study type | OBSERVATIONAL |
| Enrollment | 2 |
| Start date | 25 September 2018 |
| Primary completion | 11 November 2022 |
| Estimated completion | 11 November 2022 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Bilateral Oophorectomy Surgery
Conditions studied
- Menopause Surgical — all drugs for Menopause Surgical →
- Estrogen Deficiency — all drugs for Estrogen Deficiency →
- Adiposity — all drugs for Adiposity →
Sponsor
Pennington Biomedical Research Center — full company profile →
Who can join
Adults 18 to 45, female only, with Menopause Surgical or Estrogen Deficiency. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The overarching aim of this study is to assess the downstream effects of abrupt estrogen deficiency in women undergoing elective bilateral oophorectomy by studying: 1. the rate of in vivo adipogenesis in the subcutaneous abdominal (scABD) and subcutaneous femoral (scFEM) adipose tissue depots following bilateral oophorectomy surgery using an innovative (and tested) 8-week incorporation of stable isotope (deuterium; 2H) administered in the form of heavy water (2H2O) to endogenously label adipose tissue DNA; 2. the changes in expression of subcutaneous adipose tissue genes and proteins specific to adipocyte expansion and function; extracellular matrix remodeling and fibrosis; and inflammation in the scABD and scFEM depots before and after elective bilateral oophorectomy.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT03631680
- Europe PMC full search
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03631680 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Pennington Biomedical Research Center
- Last refreshed: 16 November 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03631680.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing