NCT03628625 is a Phase 2 clinical trial of Letrozole 2.5mg in Miscarriage, sponsored by Ain Shams Maternity Hospital.

Who is sponsoring NCT03628625?

NCT03628625 is sponsored by Ain Shams Maternity Hospital.

What drugs are being tested in NCT03628625?

Interventions in NCT03628625: Letrozole 2.5mg, Placebo, Misoprostol.

What condition does NCT03628625 study?

NCT03628625 studies Miscarriage, Missed Abortion.

Is NCT03628625 still recruiting?

NCT03628625 is currently status unknown. Last updated 9 October 2018.

Last reviewed 2018-10-09 · How we verify

NCT03628625

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Letrozole Pretreatment With Misoprostol fInduction of Abortion In First-Trimester Missed Miscarriage

Status unknown Phase 2 Last updated 9 October 2018

What this trial tests

Phase 2 trial testing Letrozole 2.5mg in Miscarriage in 80 participants. Status unknown.

Timeline

10 September 2018

Primary endpoint
5 December 2018

10 December 2018

Quick facts

Lead sponsor	Ain Shams Maternity Hospital
Phase	Phase 2
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	80
Start date	10 September 2018
Primary completion	5 December 2018
Estimated completion	10 December 2018
Sites	1 location across Egypt

Drugs / interventions tested

Letrozole 2.5mg (letrozole-2-5mg) — full drug profile →
Placebo
Misoprostol (Misoprostol) — full drug profile →

Conditions studied

Miscarriage — all drugs for Miscarriage →
Missed Abortion — all drugs for Missed Abortion →

Sponsor

Ain Shams Maternity Hospital

Who can join

18 and older, female only, with Miscarriage or Missed Abortion. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study compares the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of first trimester pregnancy.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Methods for managing miscarriage: a network meta-analysis.
Ghosh J, Papadopoulou A, Devall AJ, Jeffery HC, et al · · 2021 · cited 23× · PMID 34061352 · DOI 10.1002/14651858.cd012602.pub2
Medical methods for first trimester abortion.
Zhang J, Zhou K, Shan D, Luo X. · · 2022 · cited 19× · PMID 35608608 · DOI 10.1002/14651858.cd002855.pub5

Verify or expand the search:

Other trials of Letrozole 2.5mg

Trials testing the same drug.

NCT07109947 — Use of Aromatase Inhibitor Before Misoprostol in Medical Termination of Miscarriage · NA · recruiting
NCT07285382 — Different Doses of Dalpicicl Combined With Letrozole in the First-line Treatment of HR-positive, HER2-negative Advanced · Phase 2 · recruiting
NCT06143631 — Prescription of Letrozole for Uterine Myoma · Phase 4 · recruiting
NCT06405243 — Myoinositol, L-arginine and Chromium With Letrozole for Ovulation Induction in Polycystic Ovarian Syndrome Patients · Phase 3 · not yet recruiting
NCT06507332 — Combination Letrozole and Clomiphene Citrate Versus Letrozole Alone · NA · unknown

Other recruiting trials for Miscarriage

Currently open trials in the same condition.

NCT07109947 — Use of Aromatase Inhibitor Before Misoprostol in Medical Termination of Miscarriage · NA · recruiting
NCT06576622 — PERIodontal Disease, Microbiota and Miscarriage · recruiting
NCT06862089 — A Prospective Study Evaluating the Impact of Conservative Management on Retained Products of Conception and EMV · recruiting
NCT06452719 — Letrozole and Misoprostol for Early Pregnancy Loss Management · Phase 2 · recruiting
NCT05725512 — Prednisolone Administration in Patients With Unexplained REcurrent MIscarriages · Phase 4 · recruiting

Other Ain Shams Maternity Hospital trials

Trials by the same sponsor.

NCT07514078 — Evaluation of Laparoscopic Staging Versus Staging Laparotomy for Early Stage Endometrial Cancer · NA · not yet recruiting
NCT07308977 — Practice of Assisted Vaginal Birth in Egypt · not yet recruiting
NCT06935422 — Role of Cerebroplacental Ratio Discordance at 16-20 Weeks in Predicting Monochorionic Twin Pregnancies' Specific Complic · recruiting
NCT06524700 — Pectopexy Autologous Vs Mesh · NA · active not recruiting
NCT07247851 — Title of the Protocol: Combined Use of Vaginal Clindamycin Cream and Oral Metronidazole Versus Oral Metronidazole · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03628625 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ain Shams Maternity Hospital
Last refreshed: 9 October 2018

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03628625.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing