Who is sponsoring NCT03628534?

NCT03628534 is sponsored by Thermedical, Inc..

What drugs are being tested in NCT03628534?

Interventions in NCT03628534: Saline Enhanced Radiofrequency (SERF) ablation.

What condition does NCT03628534 study?

NCT03628534 studies Ventricular Tachycardia, Arrythmia, Heart Diseases, Cardiovascular Diseases.

Is NCT03628534 still recruiting?

NCT03628534 is currently completed. Last updated 10 August 2022.

Last reviewed 2022-08-10 · How we verify

NCT03628534: SERF VT EFS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

SERF VT Ablation Early Feasibility Study (EFS)

Completed NA Last updated 10 August 2022

What this trial tests

NA trial testing Saline Enhanced Radiofrequency (SERF) ablation in Ventricular Tachycardia in 16 participants. Completed in 31 July 2022.

Timeline

1 November 2018

Primary endpoint
30 June 2021

31 July 2022

Quick facts

Lead sponsor	Thermedical, Inc.
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	16
Start date	1 November 2018
Primary completion	30 June 2021
Estimated completion	31 July 2022
Sites	3 locations across United States

Drugs / interventions tested

Saline Enhanced Radiofrequency (SERF) ablation

Conditions studied

Ventricular Tachycardia — all drugs for Ventricular Tachycardia →
Arrythmia — all drugs for Arrythmia →
Heart Diseases — all drugs for Heart Diseases →
Cardiovascular Diseases — all drugs for Cardiovascular Diseases →

Sponsor

Thermedical, Inc.

Who can join

18 and older, any sex, with Ventricular Tachycardia or Arrythmia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is an early feasibility, non-randomized, open-label, single group, interventional study to be conducted in up to 20 US subjects to evaluate the technical feasibility of the Durablate Catheter and Thermedical Ablation System to eliminate or control sustained, monomorphic ventricular tachycardia (VT) in patients with VT refractory to drug and conventional catheter ablation with acceptable procedural safety.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Ablation of Refractory Ventricular Tachycardia Using Intramyocardial Needle Delivered Heated Saline-Enhanced Radiofrequency Energy: A First-in-Man Feasibility Trial.
Packer DL, Wilber DJ, Kapa S, Dyrda K, et al · · 2022 · cited 25× · PMID 35776711 · DOI 10.1161/circep.121.010347
Solving the Reach Problem: A Review of Present and Future Approaches for Addressing Ventricular Arrhythmias Arising from Deep Substrate.
Ravi V, Winterfield J, Liang J, Larsen T, et al · · 2023 · cited 3× · PMID 37600155 · DOI 10.15420/aer.2022.28

Verify or expand the search:

Other recruiting trials for Ventricular Tachycardia

Currently open trials in the same condition.

NCT07201506 — Real-Time Intracardiac Echocardiography for Ventricular Arrhythmia Ablation · NA · recruiting
NCT06360939 — Radiotherapy vs Catheter Ablation for Ventricular Tachycardia in Structural Heart Disease · NA · recruiting
NCT07116525 — A Study Assessing Arrhythmia Mapping With a Multi-Electrode Mapping Catheter · NA · recruiting
NCT06891456 — Pulsed Field Ablation for Post-Infarction Ventricular Tachycardia · NA · recruiting
NCT06592001 — Assessment of a Chronically Implanted Parasternally Delivered EV-ICD Lead (ASCEND EV) Study · NA · active not recruiting

Other Thermedical, Inc. trials

Trials by the same sponsor.

NCT05337241 — Saline Enhanced Radiofrequency (SERF) Needle Ablation for Refractory VT · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03628534 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Thermedical, Inc.
Last refreshed: 10 August 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03628534.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing