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NCT03626571
PET/MR Imaging In Patients With Infective Endocarditis
trial testing 18F-FDG in Infective Endocarditis in 5 participants. Completed in 28 October 2024.
28 October 2024
Quick facts
| Lead sponsor | University of Edinburgh |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 5 |
| Start date | 1 May 2018 |
| Primary completion | 28 October 2024 |
| Estimated completion | 28 October 2024 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- 18F-FDG — full drug profile →
Conditions studied
- Infective Endocarditis — all drugs for Infective Endocarditis →
Sponsor
University of Edinburgh
Who can join
30 and older, any sex, with Infective Endocarditis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
PET scanning (positron emission tomography) is a well-established technique used to identify areas of interest within the body. It involves injecting a radioactive tracer which highlights abnormal areas. It has recently been combined with CT (computed tomography) and MRI (magnetic resonance imaging) scanning to more accurately identify abnormalities within the heart. Infective endocarditis (infection of the heart valves or lining of the heart) and device infection (where a pacemaker device or wire becomes infected) are of particular interest in this area. The study makes use of hybrid PET/MR scanning using a designated scanner which enables PET scanning combined with MRI scanning. PET scanning combined with CT scanning will be used instead for patients who aren't able to undergo MRI scanning. This will allow abnormal areas within the heart in these conditions to be characterised, alongside treatment regimens, in a way which hasn't been done before. All participants will undergo PET scanning, where a radioactive tracer is injected into a vein before the scan. The radioactive substance only lasts for a short time, passed out of the body in urine. Patients with infective endocarditis involving their own heart valve will undergo an MRI scan as part of the PET scan. Patients with infective endocarditis involving a metal or prosthetic heart valve and also patients who have pacemaker infections, instead of an MRI, will have a CT scan. The reason for this is that CT is better for looking at metal and prosthetic heart valves and patients with pacemakers can't have MRI scans because the strong magnet in the scanner can affect the pacemaker. The scan will be performed twice; once before treatment and once after treatment has been established. If successful, this imaging method will play a key role in diagnosing, quantifying and monitoring these conditions.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Advanced Imaging for Detection of Foci of Infection in Staphylococcus aureus Bacteremia- Can a Scan Save Lives?
Goodman AL, Packham A, Sharkey AR, Cook GJR. · · 2023 · cited 9× · PMID 36690574 · DOI 10.1053/j.semnuclmed.2023.01.002
Verify or expand the search:
- PubMed search for NCT03626571
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Infective Endocarditis
Currently open trials in the same condition.
- NCT06269679 — CBCT vs OPT on the Oral Health Status at 12 Months of Patients Hospitalized for Infective Endocarditis. · NA · recruiting
- NCT05965362 — Prognosis of Patients With Infective Endocarditis and Risk Stratification Value of Biomarkers (ENDEAVOR） · recruiting
- NCT06418048 — INfectious DIsease REgistry BIObank · recruiting
- NCT07156292 — The Epidemiology Change From 2006 to 2022 of Infective Endocarditis in Taiwan · active not recruiting
- NCT06309680 — Accuracy of Metagenomic Blood Sampling to Identify Pathogen in Infective Endocarditis Patients · active not recruiting
Other University of Edinburgh trials
Trials by the same sponsor.
- NCT07341126 — Use of a Novel Camera to Check the Bowel After Polyp or Tumour Removal · not yet recruiting
- NCT07523997 — Imaging of Endometriosis With Total-body PET-CT (PET-Endo) · not yet recruiting
- NCT07430540 — Optimising Colorectal Cancer Patient Pathways · NA · not yet recruiting
- NCT07430527 — Secondary Care Colorectal Cancer Pathway Review · not yet recruiting
- NCT07436026 — Latin America Network for Primary Palliative Care · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03626571 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Edinburgh
- Last refreshed: 14 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03626571.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing