NCT03621631 is a NA clinical trial of Optimized Tai Chi intervention in Knee Osteoarthritis, sponsored by Edward Via Virginia College of Osteopathic Medicine.

Who is sponsoring NCT03621631?

NCT03621631 is sponsored by Edward Via Virginia College of Osteopathic Medicine.

What drugs are being tested in NCT03621631?

Interventions in NCT03621631: Optimized Tai Chi intervention, Traditional Tai Chi intervention.

What condition does NCT03621631 study?

NCT03621631 studies Knee Osteoarthritis.

Is NCT03621631 still recruiting?

NCT03621631 is currently completed. Last updated 15 September 2025.

Last reviewed 2025-09-15 · How we verify

NCT03621631

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Tai Chi Exercise on Mechanical Joint Loading in Knee Osteoarthritis

Completed NA Last updated 15 September 2025

What this trial tests

NA trial testing Optimized Tai Chi intervention in Knee Osteoarthritis in 15 participants. Completed in 31 July 2024.

Timeline

27 August 2018

Primary endpoint
31 July 2024

31 July 2024

Quick facts

Lead sponsor	Edward Via Virginia College of Osteopathic Medicine
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	15
Start date	27 August 2018
Primary completion	31 July 2024
Estimated completion	31 July 2024
Sites	1 location across United States

Drugs / interventions tested

Optimized Tai Chi intervention
Traditional Tai Chi intervention

Conditions studied

Knee Osteoarthritis — all drugs for Knee Osteoarthritis →

Sponsor

Edward Via Virginia College of Osteopathic Medicine

Who can join

Adults 40 to 80, any sex, with Knee Osteoarthritis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This project is designed to identify the biomechanical mechanisms of Tai Chi (TC) exercise and test a novel optimized TC intervention by modifying newly identified mechanisms for those with knee osteoarthritis (OA) and to assess the changes in mechanical load with the intervention. It combines unique real time torque biofeedback approach, and uses external knee adduction moment (EKAM) as modulation target tailored to TC intervention in this population. The potential benefit from this project is to provide biomechanical insights of TC and this novel TC approach may produce meaningful changes of mechanical load in these patients who can learn and practice safely during this intervention.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Exercise for osteoarthritis of the knee.
Lawford BJ, Hall M, Hinman RS, Van der Esch M, et al · · 2024 · cited 37× · PMID 39625083 · DOI 10.1002/14651858.cd004376.pub4
Optimal Tai Chi forms in knee osteoarthritis: An exploration from biomechanical rationale to pain reduction.
Yang F, Gelfond J, McGeary D, Perkins A, et al · · 2024 · cited 4× · PMID 38800823 · DOI 10.1016/j.ocarto.2024.100480
Effects of Optimal Tai Chi forms in alleviating knee pain among Hispanic people with knee osteoarthritis: A case series.
Yang F, Markides K, Reistetter TA, Moore AA, et al · · 2025 · PMID 39961273 · DOI 10.1016/j.ctcp.2025.101961

Verify or expand the search:

Other recruiting trials for Knee Osteoarthritis

Currently open trials in the same condition.

NCT06906939 — A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression · EARLY_PHASE1 · recruiting
NCT05823727 — Effects of Collagen Peptide Supplementation on Connective Tissue Remodeling, Functional Outcomes, and Wound Healing Afte · NA · recruiting
NCT07370480 — Knee Osteoarthritis and Thermal Spa Treatment · NA · recruiting
NCT07507175 — Gastrocnemius Myofascial Release in Females With Knee Osteoarthritis · NA · recruiting
NCT07386600 — Dexamethasone vs Dexmedetomidine for iPACK + ACB in TKA · NA · recruiting

Other Edward Via Virginia College of Osteopathic Medicine trials

Trials by the same sponsor.

NCT06841627 — Osteopathic Manual Therapy (OMT) and Brain Structure and Function in Primary Headache Patients: A Pilot Study · NA · completed
NCT06858592 — Osteopathic Manipulative Techniques in Collegiate Dancers · NA · completed
NCT06533345 — VCOM Pain Free Research Collaborative · NA · recruiting
NCT06529991 — Self-Myofascial Release of the Upper Cervical Muscles · NA · recruiting
NCT06471426 — The Effect of Osteopathic Treatment on Craniocervico-Mandibular Dysfunction · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03621631 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Edward Via Virginia College of Osteopathic Medicine
Last refreshed: 15 September 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03621631.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing