Last reviewed · How we verify
NCT03620825
The Effect of Dehydration on Intestinal Permeability
NA trial testing Dehydration by sauna exposure in Dehydration in 20 participants. Completed in 21 June 2018.
21 June 2018
Quick facts
| Lead sponsor | Örebro University, Sweden |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | other |
| Enrollment | 20 |
| Start date | 17 March 2018 |
| Primary completion | 21 June 2018 |
| Estimated completion | 21 June 2018 |
| Sites | 1 location across Sweden |
Drugs / interventions tested
- Dehydration by sauna exposure
- Indomethacin (INDOMETHACIN) — full drug profile →
Conditions studied
- Dehydration — all drugs for Dehydration →
- Indomethacin — all drugs for Indomethacin →
Sponsor
Örebro University, Sweden
Who can join
Adults 18 to 50, any sex, with Dehydration or Indomethacin. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In this study, the effect of dehydration by sauna exposure on the intestinal permeability in 20 healthy subjects is investigated. Participants attend three visits: 1) Sauna visit (to achieve 3% dehydration), 2) Positive control visit (intake of indomethacin which is known to increase intestinal permeability), 3) Negative control visit. At all visits, saliva samples, blood samples, faecal samples, saliva samples are collected and the multi-sugar permeability test is performed. In this test, participants drink a sugar solution and then urine collect urine for 5 and 24 h. The ratio of the sugars detected in the urine by liquid chromatography/mass spectometry is a reflection of the intestinal permeability. Saliva samples are collected for assessment of cortisol, a stress marker. Blood and faecal samples are collected for assessment of markers of intestinal barrier function and inflammation.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Sauna dehydration as a new physiological challenge model for intestinal barrier function.
Roca Rubio MF, Eriksson U, Brummer RJ, König J. · · 2021 · cited 13× · PMID 34330970 · DOI 10.1038/s41598-021-94814-0
Verify or expand the search:
- PubMed search for NCT03620825
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Dehydration
Currently open trials in the same condition.
- NCT07179107 — Adequate Hydration and Health Outcomes · NA · recruiting
- NCT07118904 — Effect of Dehydration on Sleep Quality, Cognitive Skills, and Electromyographic Responses in Combat Athletes · NA · recruiting
- NCT06824623 — Readmission and Dehydration Prevention in Patients With Elective Ileostomy · recruiting
- NCT06651619 — Efficacy of Education Versus Education Plus Prescribed Fluid Intake on Hydration Status in High School Athletes · NA · recruiting
- NCT06579950 — Assessing the Effects of Cool Roofs on Indoor Environments and Health · NA · recruiting
Other Örebro University, Sweden trials
Trials by the same sponsor.
- NCT07521709 — Evaluation of an Online ACT and Compassion-based Intervention for Disorders of Gut-Brain Interaction · NA · not yet recruiting
- NCT07350239 — Clinical, Microbial and Tissue-based Characterization of Patients Treated for Severe Temporomandibular Joint Pathology · not yet recruiting
- NCT07527793 — Monitoring Changes in Blood Circulating Metabolites Using Minimally Invasive Techniques · NA · recruiting
- NCT07175402 — Feasibility and Acceptability of an Online ACT Intervention for Disorders of Gut-Brain Interaction - Beta Trial · NA · completed
- NCT06887751 — Feasibility and Acceptability of an Online ACT Intervention for Disorders of Gut-Brain Interaction · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03620825 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Örebro University, Sweden
- Last refreshed: 8 August 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03620825.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing