NCT03618511

Interventions to Improve HIV Antiretroviral Therapy Adherence

Completed NA Last updated 24 September 2021

What this trial tests

NA trial testing Financial Incentive in Human Immunodeficiency Virus (HIV) Infection in 914 participants. Completed in 30 April 2021.

Timeline

6 August 2018

Primary endpoint
30 April 2021

30 April 2021

Quick facts

Lead sponsor	University of Michigan
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	health services research
Enrollment	914
Start date	6 August 2018
Primary completion	30 April 2021
Estimated completion	30 April 2021
Sites	1 location across Mozambique

Drugs / interventions tested

• Financial Incentive
• Reminders
• Financial Incentive and Reminders
• Information
• Stigma-relieving
• Information and Stigma-relieving

Conditions studied

• Human Immunodeficiency Virus (HIV) Infection — all drugs for Human Immunodeficiency Virus (HIV) Infection →

Sponsor

University of Michigan

Who can join

18 and older, any sex, with Human Immunodeficiency Virus (HIV) Infection. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will explore whether financial incentives, reminders, information about HIV/AIDS and its treatment and anti-stigma counseling help improve anti-retroviral therapy (ART) adherence among HIV infected individuals in a resource-limited environment. The interventions will be randomized in the study population in a cross-cutting design, with a control group, a financial incentive treatment group, a reminders treatment group, a treatment group that receives both the financial incentive and reminder interventions. In addition, there will be an information treatment group, a stigma-relieving treatment group and a group that receives both information and stigma-relieving interventions. The primary outcomes of interest for this study will be the adherence to ART, measured by attendance rates at clinic appointments and refill collection rates.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Accuracy of measures for antiretroviral adherence in people living with HIV.
   Smith R, Villanueva G, Probyn K, Sguassero Y, et al · · 2022 · cited 34× · PMID 35871531 · DOI 10.1002/14651858.cd013080.pub2