NCT03615092

Acellular Dermal Matrix Graft In Root Coverage of Gingival Recessions With Previously Restored Cervical Lesions

Completed NA Last updated 7 August 2018

What this trial tests

NA trial testing Root coverage with extended flap technique and acelular dermal matrix in Gingival Recession in 17 participants. Completed in 13 July 2018.

Timeline

30 January 2011

Primary endpoint
5 October 2011

13 July 2018

Quick facts

Lead sponsor	University of Sao Paulo
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	17
Start date	30 January 2011
Primary completion	5 October 2011
Estimated completion	13 July 2018
Sites	1 location across Brazil

Drugs / interventions tested

• Root coverage with extended flap technique and acelular dermal matrix

Conditions studied

• Gingival Recession — all drugs for Gingival Recession →

Sponsor

University of Sao Paulo

Who can join

Adults 18 to 70, any sex, with Gingival Recession. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Patients with high standards of oral hygiene frequently search for buccal gingival recession (GR) treatment due to cervical wear, root sensitivity and compromising aesthetics. The cervical lesion (NCCL) is commonly produced by improper toothbrushing techniques, sharing the same etiology of GR. Many different surgical approaches have been described. The association of a graft to the coronally advanced flap had demonstrated the best long-term outcome for root coverage. But, substitutes for the autogenous graft must be studied. Therefore, the aim of this clinical trial was to investigate the effectiveness of the acellular dermal matrix graft (ADMG) in root coverage associated with a previous restored cervical lesion or not.

Material and methods: Seventeen individuals with bilateral GR were included in the study. At one side, the GR must present a previously restored cervical lesion, as the test group (TG). The contralateral arch, must present GR with an intact root surface (CG). All patients were treated with the extended flap technique associated with the ADMG. All clinical parameters were assessed at baseline and 6-months postoperative.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Current state about root coverage using soft-tissue substitutes in the presence of noncarious cervical lesions: A literature review.
   Huamán-Mendoza AA, Reis INRD, Ganhito JA, Carvalho CV, et al · · 2023 · cited 1× · PMID 37593556 · DOI 10.4103/jisp.jisp_388_22