NCT03613961 is a clinical trial of Anesthetics in Autonomic Nervous System Imbalance, sponsored by National Central University.

Who is sponsoring NCT03613961?

NCT03613961 is sponsored by National Central University.

What drugs are being tested in NCT03613961?

Interventions in NCT03613961: Anesthetics.

What condition does NCT03613961 study?

NCT03613961 studies Autonomic Nervous System Imbalance.

Is NCT03613961 still recruiting?

NCT03613961 is currently completed. Last updated 9 January 2020.

Last reviewed 2020-01-09 · How we verify

NCT03613961

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effects of Propofol Induction Anaesthesia on the Heart Rate Variability

Completed Last updated 9 January 2020

What this trial tests

trial testing Anesthetics in Autonomic Nervous System Imbalance in 30 participants. Completed in 1 July 2018.

Timeline

25 July 2017

Primary endpoint
1 July 2018

1 July 2018

Quick facts

Lead sponsor	National Central University
Status	Completed
Study type	OBSERVATIONAL
Enrollment	30
Start date	25 July 2017
Primary completion	1 July 2018
Estimated completion	1 July 2018
Sites	1 location across Taiwan

Drugs / interventions tested

Anesthetics — full drug profile →

Conditions studied

Autonomic Nervous System Imbalance — all drugs for Autonomic Nervous System Imbalance →

Sponsor

National Central University

Who can join

Adults 20 to 60, any sex, with Autonomic Nervous System Imbalance. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The ANS plays an important role in the regulation of hemodynamics during anesthesia. Manually blous of propofol during induction anesthesia is reported to reduce both sympathetic and parasympathetic tone; however, it is not clear whether the changes in heart rate variability are associated with propofol concentration.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Strong Early Phase Parasympathetic Inhibition Followed by Sympathetic Withdrawal During Propofol Induction: Temporal Response Assessed by Wavelet-Based Spectral Analysis and Photoplethysmography.
Wang HY, Lo MT, Chen KH, Mandell S, et al · · 2021 · cited 3× · PMID 34588990 · DOI 10.3389/fphys.2021.705153

Verify or expand the search:

Other recruiting trials for Autonomic Nervous System Imbalance

Currently open trials in the same condition.

NCT06359808 — Clinical Characteristics of Sleep Disorders in Patients With Ulcerative Colitis · recruiting
NCT05212129 — Auricular Vagal Nerve Stimulation for Hypermobile Ehlers-Danlos Syndrome · NA · recruiting

Other National Central University trials

Trials by the same sponsor.

NCT03954262 — Autonomic Modulation After Propofol Target Controlled Infusion and Bolus Administration · completed
NCT04275375 — Autonomic Modulation After Spinal Anesthesia With Depth of Anesthesia and Vital Signs. · completed
NCT03072069 — Analysis of Autonomic Function During Anesthesia Using Response Surface Model · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03613961 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by National Central University
Last refreshed: 9 January 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03613961.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing