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NCT03613506
The Role and Intervention of TGF-β in Abdominal Radiation Injury
Phase 2 trial testing Captopril 12.5 Mg in Radiotherapy Side Effect in 226 participants. Status unknown.
25 June 2022
Quick facts
| Lead sponsor | Wuhan University |
|---|---|
| Phase | Phase 2 |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 226 |
| Start date | 25 October 2019 |
| Primary completion | 25 June 2022 |
| Estimated completion | 25 December 2022 |
| Sites | 1 location across China |
Drugs / interventions tested
- Captopril 12.5 Mg — full drug profile →
Conditions studied
- Radiotherapy Side Effect — all drugs for Radiotherapy Side Effect →
- Taking Captopril — all drugs for Taking Captopril →
Sponsor
Wuhan University
Who can join
Adults 18 to 70, any sex, with Radiotherapy Side Effect or Taking Captopril. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This project aims to investigate the relationship between radiation-induced the relationship between elevated peripheral blood TGFβ and complications of radiotherapy,and to analysis of changes in peripheral blood TGFβ levels after abdominal radiotherapy and its relationship with radiotherapy complications.Simultaneously,Patients who underwent abdominal radiotherapy were given captopril (sustained release) to block TGFβ,Whether it can reduce peripheral blood TGFβ levels and reduce radiotherapy complications,to explore the protective effect of blocking TGFβ secretion on normal tissues after radiotherapy.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT03613506
- Europe PMC full search
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Other Wuhan University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03613506 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Wuhan University
- Last refreshed: 14 February 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03613506.
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