Last reviewed · How we verify
NCT03613246: FOLLOW
NVT ALLEGRA TAVI System TF in Failing Calcified Aortic Heart Valves in a Real-world Patient Population
trial in Transcatheter Aortic Valve Implantation in 346 participants. Participants enrolled and being followed up; not accepting new ones.
20 December 2024
Quick facts
| Lead sponsor | NVT GmbH |
|---|---|
| Status | Active, enrolled |
| Study type | OBSERVATIONAL |
| Enrollment | 346 |
| Start date | 20 February 2019 |
| Primary completion | 20 December 2024 |
| Estimated completion | 26 January 2029 |
| Sites | 14 locations across Italy, Finland, Netherlands, United Kingdom, Germany, Spain |
Conditions studied
- Transcatheter Aortic Valve Implantation — all drugs for Transcatheter Aortic Valve Implantation →
Sponsor
NVT GmbH
Who can join
18 and older, any sex, with Transcatheter Aortic Valve Implantation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The study collects real-world data of patients who were treated with the ALLEGRA TAVI System TF and evaluates early and midterm clinical and quality of life outcome.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
A European update on transcatheter aortic valve implantation (TAVI) in the COVID era.
Antony I, Mehari Abraha H, Hameed A, Conway C. · · 2023 · cited 6× · PMID 36152032 · DOI 10.1111/joa.13740
Verify or expand the search:
- PubMed search for NCT03613246
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Transcatheter Aortic Valve Implantation
Currently open trials in the same condition.
- NCT06773780 — Transcatheter Aortic Valve Implantation: Comparison of the Effects of Ultrasound-Guided Pericapsular Nerve Group Block a · NA · recruiting
- NCT06602609 — Remote Cardiovascular Monitoring in Post-TAVI Patients · NA · recruiting
- NCT06896227 — TAVR: The Impact of Prothesis Positioning on Valvular and Coronary Hemodynamics · NA · recruiting
- NCT06481137 — Reversibility of Cardiac Conduction Disturbances Following TAVI · NA · recruiting
- NCT06189976 — Rapid Atrial Pacing After TAVI to Predict Pacemaker Implantation · NA · recruiting
Other NVT GmbH trials
Trials by the same sponsor.
- NCT05804903 — Investigation of the NVT ALLEGRA Plus THV System in Patients With Severe Aortic Stenosis or Failed Surgical Aortic Biopr · NA · suspended
- NCT05478161 — Investigation of the ALLEGRA THV System With a New Delivery System in Patients With Aortic Stenosis or Failed Surgical B · NA · completed
- NCT03287856 — NVT ALLEGRA TAVI System TF in Failing Surgical Aortic Bioprosthesis · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03613246 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by NVT GmbH
- Last refreshed: 17 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03613246.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing