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NCT03610386: DA-TRPM8

Effects of an Anti-TRPM8 in the Atopic Dermatitis Pruritus

Completed NA Last updated 28 December 2021
What this trial tests

NA trial testing Adding menthoxypropanediol to the biopsy in Atopic Dermatitis in 10 participants. Completed in 29 January 2019.

Timeline
21 November 2018
Primary endpoint
29 January 2019
29 January 2019

Quick facts

Lead sponsorUniversity Hospital, Brest
PhaseNA
StatusCompleted
Study typeINTERVENTIONAL
Allocationnon randomized
Designparallel
Maskingnone
Primary purposetreatment
Enrollment10
Start date21 November 2018
Primary completion29 January 2019
Estimated completion29 January 2019
Sites1 location across France

Drugs / interventions tested

Conditions studied

Sponsor

University Hospital, Brest

Who can join

18 and older, any sex, with Atopic Dermatitis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of the study is to analyse the effect of the menthoxypropanediol, a derivative of menthol, on the pruritus of atopic dermatitis (ex vivo study).

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

  1. TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases.
    Zhang M, Ma Y, Ye X, Zhang N, et al · · 2023 · cited 303× · PMID 37402746 · DOI 10.1038/s41392-023-01464-x
  2. TRPM8 Channels: Advances in Structural Studies and Pharmacological Modulation.
    Izquierdo C, Martín-Martínez M, Gómez-Monterrey I, González-Muñiz R. · · 2021 · cited 54× · PMID 34445208 · DOI 10.3390/ijms22168502
  3. New and Upcoming Topical Treatments for Atopic Dermatitis: A Review of the Literature.
    Sideris N, Paschou E, Bakirtzi K, Kiritsi D, et al · · 2022 · cited 28× · PMID 36078904 · DOI 10.3390/jcm11174974
  4. Physiological functions and pharmacological targeting of transient receptor potential channels.
    Chubanov V, Grimm C, Hill K, Schaefer M, et al · · 2025 · PMID 41118703 · DOI 10.1016/j.pharmr.2025.100089

Verify or expand the search:

Other recruiting trials for Atopic Dermatitis

Currently open trials in the same condition.

Other University Hospital, Brest trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03610386.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing