Helicobacter Rescue Therapy With Berberine Plus Amoxicillin Quadruple Therapy Versus Tetracycline Plus Furazolidone Quadruple Therapy

NCT03609892 PHASE4 COMPLETED

This study aims at evaluating efficacy and safety of berberine- amoxicillin containing quadruple therapy(berberine, amoxicillin, esomeprazole and bismuth) versus tetracycline-furazolidone quadruple therapy (tetracycline, furazolidone, esomeprazole and bismuth) in H. pylori rescue therapy. It is hypothesized that berberine-amoxicillin containing quadruple therapy is non-inferior to tetracycline-furazolidone quadruple therapy. Patients with confirmed failure of H. pylori eradication will be randomized to one of the treatments described above. At week 6 follow-up visits, a urea breath test，rapid urease test or helicobacter pylori stool antigen test will be performed to confirm eradication.

Details

Lead sponsor	Xijing Hospital of Digestive Diseases
Phase	PHASE4
Status	COMPLETED
Enrolment	658
Start date	Wed Aug 01 2018 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Tue Aug 20 2019 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Gastric Ulcer
• Chronic Gastritis
• Gastric Cancer
• Helicobacter Pylori Infection
• Gastritis

Interventions

• Berberine
• Amoxicillin
• Esomeprazole
• Bismuth
• Tetracycline
• Furazolidone
• Esomeprazole
• Bismuth

Countries

China