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NCT03609437: ESUS
Impaired Endothelial Integrity in Patients With Embolic Stroke of Undetermined Source (ESUS)
trial in Embolic Stroke of Undetermined Source in 215 participants. Participants enrolled and being followed up; not accepting new ones.
30 October 2025
Quick facts
| Lead sponsor | University of Athens |
|---|---|
| Status | Active, enrolled |
| Study type | OBSERVATIONAL |
| Enrollment | 215 |
| Start date | 1 January 2018 |
| Primary completion | 30 October 2025 |
| Estimated completion | 30 June 2026 |
| Sites | 1 location across Greece |
Conditions studied
- Embolic Stroke of Undetermined Source — all drugs for Embolic Stroke of Undetermined Source →
- Endothelial Dysfunction — all drugs for Endothelial Dysfunction →
Sponsor
University of Athens
Who can join
Adults 18 to 75, any sex, with Embolic Stroke of Undetermined Source or Endothelial Dysfunction. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The investigators will measure endothelial glycocalyx, aortic elastic properties, oxidative stress, and their association with left ventricular (LV) and left atrial (LA) function in ESUS, cardioembolic, atherosclerotic, lacunar strokes and age- and sex-adjusted healthy individuals.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Impaired Arterial Elastic Properties and Endothelial Glycocalyx in Patients with Embolic Stroke of Undetermined Source.
Ikonomidis I, Frogoudaki A, Vrettou AR, Andreou I, et al · · 2019 · cited 18× · PMID 31421641 · DOI 10.1055/s-0039-1694752
Verify or expand the search:
- PubMed search for NCT03609437
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Embolic Stroke of Undetermined Source
Currently open trials in the same condition.
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Other University of Athens trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03609437 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Athens
- Last refreshed: 15 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03609437.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing