NCT03609333: CAMPHIBIII

Characterizing the cerebrovAscular Physiology of Optimal Mean Arterial Pressure Targeted Resuscitation

Completed NA Last updated 3 November 2020

What this trial tests

NA trial testing Multimodal Neuromonitoring in Cardiac Arrest in 20 participants. Completed in 30 June 2020.

Timeline

12 November 2016

Primary endpoint
30 June 2020

30 June 2020

Quick facts

Lead sponsor	University of British Columbia
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Primary purpose	basic science
Enrollment	20
Start date	12 November 2016
Primary completion	30 June 2020
Estimated completion	30 June 2020
Sites	1 location across Canada

Drugs / interventions tested

• Multimodal Neuromonitoring

Conditions studied

• Cardiac Arrest — all drugs for Cardiac Arrest →

Sponsor

University of British Columbia

Who can join

18 and older, any sex, with Cardiac Arrest. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Hypoxic ischemic brain injury is a devastating illness that occurs after cardiac arrest (the heart stopping) and can yield irreversible brain damage, often leading to death. The mainstay in therapy is to optimize the delivery of oxygen to the brain to help it recover. In patients with traumatic brain injury (similar to HIBI), the investigators are able to optimize oxygen delivery to the brain with the use of wires placed into the brain that sense the pressure and oxygen in the skull to find the ideal blood pressure for each individual patient. This strategy is associated with improved outcomes. The investigators are conducting a prospective study investigating whether the perfusion within proximity to the optimal MAP is associated with improved brain oxygenation and blood flow .

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Brain Hypoxia Is Associated With Neuroglial Injury in Humans Post-Cardiac Arrest.
   Hoiland RL, Ainslie PN, Wellington CL, Cooper J, et al · · 2021 · cited 62× · PMID 34287000 · DOI 10.1161/circresaha.121.319157
2. Intracranial pressure and compliance in hypoxic ischemic brain injury patients after cardiac arrest.
   Sekhon MS, Griesdale DE, Ainslie PN, Gooderham P, et al · · 2019 · cited 49× · PMID 31185256 · DOI 10.1016/j.resuscitation.2019.05.036