Who is sponsoring NCT03608254?

NCT03608254 is sponsored by University of Alabama, Tuscaloosa.

What drugs are being tested in NCT03608254?

Interventions in NCT03608254: 100% watermelon juice.

What condition does NCT03608254 study?

NCT03608254 studies Vascular Health of Postmenopausal Women.

Is NCT03608254 still recruiting?

NCT03608254 is currently completed. Last updated 14 March 2022.

Are results published for NCT03608254?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2022-03-14 · How we verify

NCT03608254

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Acute Effects of Watermelon on Vascular Function and Serum Lycopene

Completed Results posted Last updated 14 March 2022

What this trial tests

trial testing 100% watermelon juice in Vascular Health of Postmenopausal Women in 11 participants. Completed in 8 December 2016.

Timeline

5 November 2015

Primary endpoint
8 December 2016

8 December 2016

Quick facts

Lead sponsor	University of Alabama, Tuscaloosa
Status	Completed
Study type	OBSERVATIONAL
Enrollment	11
Start date	5 November 2015
Primary completion	8 December 2016
Estimated completion	8 December 2016
Sites	1 location across United States

Drugs / interventions tested

100% watermelon juice

Conditions studied

Vascular Health of Postmenopausal Women — all drugs for Vascular Health of Postmenopausal Women →

Sponsor

University of Alabama, Tuscaloosa

Who can join

Adults 65 to 70, female only, with Vascular Health of Postmenopausal Women. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Change From Baseline in Circulating Lycopene Levels Primary · 2 hours post-ingestion

On the testing day, participants reported to the clinic following a 10-hour overnight fast. Blood samples were obtained by standard venipuncture at baseline and two hours after ingestion of a 360 ml dose of 100% pasteurized watermelon juice in order to determine change in serum lycopene levels.

Group	Value	95% CI
Watermelon Juice	2.85	± 0.66

Change From Baseline in Endothelial-dependent Vasodilation Secondary · 2 hours post-ingestion

Brachial artery flow-mediated dilation (FMD) was used to assess endothelial-dependent vasodilation. FMD uses ultrasound technology to quantify changes in brachial artery diameter in response to hyperemia. A blood pressure cuff was placed distal to the brachial artery of the right arm with the participant supine and rested. Pre-inflation diameter was recorded for one minute, and the cuff was inflated to 50 mmHg above resting SBP for five minutes. Then, images were recorded for 120 seconds after cuff deflation. Peak diameter was determined as an average of the five highest measurements over five

Group	Value	95% CI
Watermelon Juice	2.33	± 7.33

Sponsor's own description

This study aimed to examine the effects of a one-time dose of 100% watermelon juice on circulating lycopene levels and measures of vascular health among a cohort of postmenopausal women.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Watermelon Juice: a Novel Functional Food to Increase Circulating Lycopene in Older Adult Women.
Ellis AC, Dudenbostel T, Crowe-White K. · · 2019 · cited 10× · PMID 30756297 · DOI 10.1007/s11130-019-00719-9

Verify or expand the search:

Other trials of 100% watermelon juice

Trials testing the same drug.

NCT03626168 — Bioactive Compounds in Watermelon Modulating Oxidative Stress and Inflammation in Elders · NA · completed

Other University of Alabama, Tuscaloosa trials

Trials by the same sponsor.

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NCT05632575 — The Virtual Promotoras Study: eHealth Intervention to Promote Sexual Health Among Young Latina Women in the US South · NA · completed
NCT06076967 — Mindfulness Intervention for College Students With ADHD · NA · recruiting
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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03608254 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Alabama, Tuscaloosa
Last refreshed: 14 March 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03608254.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing