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NCT03601364
The Effects of Peep and Tidal Volume on Oxidative Stress in Cardiopulmonary Bypass Surgery
trial in Cardiac Surgery in 60 participants. Completed in 10 March 2019.
1 March 2019
Quick facts
| Lead sponsor | Kahramanmaras Sutcu Imam University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 60 |
| Start date | 1 August 2018 |
| Primary completion | 1 March 2019 |
| Estimated completion | 10 March 2019 |
| Sites | 1 location across Turkey (Türkiye) |
Conditions studied
- Cardiac Surgery — all drugs for Cardiac Surgery →
- Oxidative Stress — all drugs for Oxidative Stress →
Sponsor
Kahramanmaras Sutcu Imam University
Who can join
Adults 18 to 80, any sex, with Cardiac Surgery or Oxidative Stress. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Although cardio-pulmonary bypass surgery (CPBS) is a routine procedure worldwide, patient morbidity and mortality are still high due to postoperative negative complications.Inflammatory response and systemic oxidative stress have been reported to be directly related to this practice.Mechanisms explaining this condition have been described as being related to several events that occur during the cardiopulmonary bypass (CPBS), where blood is exposed to non-physiological surfaces, surgical trauma, ischemia-reperfusion, and changes in body temperature.In addition, CPB induces atelectasis and affects the structure of the bronchoalveolar tree.Prolongation of atelectasis may facilitate proinflammatory cytokine production by macrophages.One of the most damaging consequences of all these events is the formation of reactive oxygen species (ROS) and radicals originating from various cellular and enzymatic sources such as myocardial cells, activated neutrophils.ROS has toxic effects on cellular structures including lipids, proteins and nucleic acids.Oxidative reaction damages cellular function and may increase perioperative or postoperative complications after CPBS.Total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) reflect the redox balance between oxidation and antioxidation.TAS measurement is an indication of the activity of all antioxidants and TOS is an indicator of ROS.OSI is a measure of the ratio of TOS to TAS and the level of Oxidative Stress (OS).The contribution of various mechanisms to oxidant-antioxidant balance during on-pump coronary artery bypass grafting (ONCABG) has not yet been fully evaluated. The investigator's aim in this study is to investigate the effect of lung protective mechanism (Tidal Volum, PEEP) on oxidative stress parameters such as TAS, TOS, Thiol / Disulphide, Catalase, Glutathione Peroxidase, MDA (Melanil Dialdehyde) in cardio pulmonary bypass surgery
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
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Effect of mechanical ventilation during cardiopulmonary bypass on oxidative stress: a randomized clinical trial.
Orak Y, Baylan FA, Kocaslan A, Eroglu E, et al · · 2022 · cited 4× · PMID 34274366 · DOI 10.1016/j.bjane.2021.06.024
Verify or expand the search:
- PubMed search for NCT03601364
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03601364 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Kahramanmaras Sutcu Imam University
- Last refreshed: 24 September 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03601364.
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