NCT03599427 is a Phase 4 clinical trial of systemic lidocaine in Surgery, sponsored by Algemeen Ziekenhuis Maria Middelares.

Who is sponsoring NCT03599427?

NCT03599427 is sponsored by Algemeen Ziekenhuis Maria Middelares.

What drugs are being tested in NCT03599427?

Interventions in NCT03599427: systemic lidocaine, Placebo.

What condition does NCT03599427 study?

NCT03599427 studies Surgery, Pain, Postoperative, Nausea, Postoperative, Opioid Use.

Is NCT03599427 still recruiting?

NCT03599427 is currently completed. Last updated 10 October 2019.

Last reviewed 2019-10-10 · How we verify

NCT03599427

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Added Value of Systemic Lidocaine on Postoperative Pain, Opiate Use and Nausea After Knee Arthroscopy

Completed Phase 4 Last updated 10 October 2019

What this trial tests

Phase 4 trial testing systemic lidocaine in Surgery in 60 participants. Completed in 30 June 2019.

Timeline

1 September 2018

Primary endpoint
1 June 2019

30 June 2019

Quick facts

Lead sponsor	Algemeen Ziekenhuis Maria Middelares
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	supportive care
Enrollment	60
Start date	1 September 2018
Primary completion	1 June 2019
Estimated completion	30 June 2019
Sites	1 location across Belgium

Drugs / interventions tested

systemic lidocaine — full drug profile →
Placebo

Conditions studied

Surgery — all drugs for Surgery →
Pain, Postoperative — all drugs for Pain, Postoperative →
Nausea, Postoperative — all drugs for Nausea, Postoperative →
Opioid Use — all drugs for Opioid Use →

Sponsor

Algemeen Ziekenhuis Maria Middelares — full company profile →

Who can join

18 and older, any sex, with Surgery or Pain, Postoperative. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Local intra-articular injection of anesthetics (LIA) is increasingly used during knee arthroscopy for pain relief. The LIA can only be performed at the end of surgery as the knee joint is continuously flushed during the arthroscopy. As a consequence, an optimal analgesic effect is only obtained one hour after surgery and opiates are typically used as pain relief in the immediate postoperative period. Since these opiates have a number of side effects such as nausea, vomiting and drowsiness, other analgetic methods are desirable. Intravenous administration of lidocaine, a safe, inexpensive analgesic, is already used in major (abdominal) surgeries and might also be a promising method for pain relief in the first hour after knee arthroscopy, in anticipation of the onset of the analgesic effect of the LIA. The aim of this study is to verify if systemic administration of lidocaine has a beneficial effect on the pain immediately after knee arthroscopy. In addition, the effect of systemic lidocaine administration on postoperative nausea, vomiting and general patient comfort will be evaluated.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other recruiting trials for Surgery

Currently open trials in the same condition.

NCT07369921 — Pediatric Pilonidal Sinus Surgical Treatment · NA · recruiting
NCT07362303 — Neuralert Stroke Monitor Trial · NA · recruiting
NCT07404163 — Walkway Used in Postoperative Mobilization · NA · active not recruiting
NCT07218289 — Green Light for Post-Operative Wellness · NA · recruiting
NCT07342751 — The Effect of Listening to Music During Mobilization on Pain and Fear in Children Undergoing Abdominal Surgery · NA · active not recruiting

Other Algemeen Ziekenhuis Maria Middelares trials

Trials by the same sponsor.

NCT05575141 — Robotic Versus Open Comparison in the Surgical Treatment of Wide Abdominal Wall heRnias (ROCSTAR) · NA · not yet recruiting
NCT06080178 — Goal-directed Fluid Therapy During Deep Inferior Epigastric Perforator (DIEP) Free Flap Breast Reconstruction · Phase 4 · recruiting
NCT06599515 — SetUp Study for HugoTM RAS Inguinal Hernia Repair · NA · recruiting
NCT06835426 — High-resolution PET-CT Specimen Imaging for the Perioperative Visualization of Resection Margins · NA · recruiting
NCT05939206 — rTARUP: Long-term Analysis · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03599427 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Algemeen Ziekenhuis Maria Middelares
Last refreshed: 10 October 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03599427.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing