NCT03595540 is a NA clinical trial of Prolon in Cancer, sponsored by University of Genova.

Who is sponsoring NCT03595540?

NCT03595540 is sponsored by University of Genova.

What drugs are being tested in NCT03595540?

Interventions in NCT03595540: Prolon.

What condition does NCT03595540 study?

NCT03595540 studies Cancer, Breast Cancer, Colorectal Cancer.

Is NCT03595540 still recruiting?

NCT03595540 is currently completed. Last updated 20 October 2022.

Last reviewed 2022-10-20 · How we verify

NCT03595540

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Fasting-mimicking Diet in Patients Undergoing Active Cancer Treatment

Completed NA Last updated 20 October 2022

What this trial tests

NA trial testing Prolon in Cancer in 90 participants. Completed in 15 April 2021.

Timeline

22 November 2017

Primary endpoint
15 April 2021

15 April 2021

Quick facts

Lead sponsor	University of Genova
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	other
Enrollment	90
Start date	22 November 2017
Primary completion	15 April 2021
Estimated completion	15 April 2021
Sites	1 location across Italy

Drugs / interventions tested

Prolon

Conditions studied

Cancer — all drugs for Cancer →
Breast Cancer — all drugs for Breast Cancer →
Colorectal Cancer — all drugs for Colorectal Cancer →

Sponsor

University of Genova

Who can join

18 and older, any sex, with Cancer or Breast Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a pilot, single arm prospective trial assessing feasibility, safety and effects on patient nutritional status of a 5-day fasting-mimicking diet (FMD) in patients with different cancer types and concomitant anticancer treatment.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

Metabolic Regulation of Macrophage Polarization in Cancer.
Mehla K, Singh PK. · · 2019 · cited 470× · PMID 31813459 · DOI 10.1016/j.trecan.2019.10.007
Fasting-mimicking diet and hormone therapy induce breast cancer regression.
Caffa I, Spagnolo V, Vernieri C, Valdemarin F, et al · · 2020 · cited 263× · PMID 32669709 · DOI 10.1038/s41586-020-2502-7
Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications.
Zhong X, He X, Wang Y, Hu Z, et al · · 2022 · cited 223× · PMID 36319992 · DOI 10.1186/s13045-022-01358-5
Insulin-Like Growth Factor 1 (IGF-1) Signaling in Glucose Metabolism in Colorectal Cancer.
Kasprzak A. · · 2021 · cited 169× · PMID 34208601 · DOI 10.3390/ijms22126434
Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential.
Xiao YL, Gong Y, Qi YJ, Shao ZM, et al · · 2024 · cited 120× · PMID 38462638 · DOI 10.1038/s41392-024-01771-x
Effects of short-term fasting on cancer treatment.
de Groot S, Pijl H, van der Hoeven JJM, Kroep JR. · · 2019 · cited 87× · PMID 31113478 · DOI 10.1186/s13046-019-1189-9
Modulating gut microbiome in cancer immunotherapy: Harnessing microbes to enhance treatment efficacy.
Kang X, Lau HC, Yu J. · · 2024 · cited 65× · PMID 38631285 · DOI 10.1016/j.xcrm.2024.101478
Nutrients in the Prevention of Alzheimer's Disease.
Cremonini AL, Caffa I, Cea M, Nencioni A, et al · · 2019 · cited 65× · PMID 31565158 · DOI 10.1155/2019/9874159

Verify or expand the search:

Other trials of Prolon

Trials testing the same drug.

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Currently open trials in the same condition.

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Other University of Genova trials

Trials by the same sponsor.

NCT07351435 — The Caribbean Registry of Extracorporeal Membrane Oxygenation (ECMO) From the University Hospital in Martinique · not yet recruiting
NCT06689020 — Positive Expiratory Pressure (PEP) and Continuous High-frequency Oscillation (CHFO) on Lung RECRUITment Using Electrical · not yet recruiting
NCT06367816 — Brain Recovery With Automated VEntilation · completed
NCT05467579 — Mandibular Advancement Clear Aligner Treatment in Juvenile Idiopathic Arthritis Subjects · NA · unknown
NCT05135962 — Maxillary Expansion: Leaf Expander Versus Hyrax Expander · NA · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03595540 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Genova
Last refreshed: 20 October 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03595540.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing