NCT03595098: TECTO

Treatment Effects of Family Based Cognitive Therapy in Children and Adolescents With Obsessive Compulsive Disorder

Active, enrolled NA Last updated 5 July 2024

What this trial tests

NA trial testing Family Based Cognitive Behavioural Therapy in Obsessive-Compulsive Disorder in Children in 128 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

28 August 2018

Primary endpoint
7 April 2022

31 December 2027

Quick facts

Lead sponsor	Anne Katrine Pagsberg
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	128
Start date	28 August 2018
Primary completion	7 April 2022
Estimated completion	31 December 2027
Sites	1 location across Denmark

Drugs / interventions tested

• Family Based Cognitive Behavioural Therapy
• Family Based Psychoeducation/Relaxation Training

Conditions studied

• Obsessive-Compulsive Disorder in Children — all drugs for Obsessive-Compulsive Disorder in Children →
• Obsessive-Compulsive Disorder in Adolescence — all drugs for Obsessive-Compulsive Disorder in Adolescence →

Sponsor

Anne Katrine Pagsberg

Who can join

Adults 8 to 17, any sex, with Obsessive-Compulsive Disorder in Children or Obsessive-Compulsive Disorder in Adolescence. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

To investigate the benefits and harms, and the neural and neurocognitive mediators of treatment response, in family-based cognitive behavioural therapy versus family-based psychoeducation and relaxation training in children and adolescents with obsessive compulsive disorder. The aim is to conduct this investigation in an optimal trial design with the lowest possible risk of bias.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Obsessive-compulsive disorder.
   Stein DJ, Costa DLC, Lochner C, Miguel EC, et al · · 2019 · cited 495× · PMID 31371720 · DOI 10.1038/s41572-019-0102-3
2. Family-based cognitive behavioural therapy versus family-based relaxation therapy for obsessive-compulsive disorder in children and adolescents: protocol for a randomised clinical trial (the TECTO trial).
   Pagsberg AK, Uhre C, Uhre V, Pretzmann L, et al · · 2022 · cited 15× · PMID 35305587 · DOI 10.1186/s12888-021-03669-2
3. Atypical neurocognitive functioning in children and adolescents with obsessive-compulsive disorder (OCD).
   Uhre CF, Ritter M, Jepsen JRM, Uhre VF, et al · · 2024 · cited 5× · PMID 37917157 · DOI 10.1007/s00787-023-02301-w
4. The association between salivary oxytocin, age, and puberty in children with and without OCD.
   Mora-Jensen AC, Clemmensen LKH, Grønberg MG, Lebowitz ER, et al · · 2024 · cited 3× · PMID 39562644 · DOI 10.1038/s41598-024-80194-8
5. Emotion dysregulation in youths with obsessive-compulsive disorder and its implication for treatment - An exploratory study from the TECTO trial: A protocol and statistical analysis plan.
   Thoustrup CL, Uhre C, Uhre V, Ritter M, et al · · 2025 · cited 2× · PMID 39802662 · DOI 10.1016/j.conctc.2024.101408
6. Family-based cognitive behavioural therapy versus family-based relaxation therapy for obsessive-compulsive disorder in children and adolescents (the TECTO trial): a statistical analysis plan for the randomised clinical trial.
   Olsen MH, Hagstrøm J, Lønfeldt NN, Uhre C, et al · · 2022 · cited 2× · PMID 36203215 · DOI 10.1186/s13063-022-06799-4
7. Family-based cognitive behavioral therapy versus family-based psychoeducation and relaxation training for obsessive-compulsive disorder in children and adolescents: a randomized clinical trial (TECTO).
   Pagsberg AK, Lønfeldt NN, Thoustrup CL, Korsbjerg NLJ, et al · · 2025 · cited 1× · PMID 40742552 · DOI 10.1007/s00787-025-02797-4
8. Adverse events in cognitive behavioral therapy and relaxation training for children and adolescents with obsessive-compulsive disorder: A mixed methods study and analysis plan for the TECTO trial.
   Pretzmann L, Christensen SH, Bryde Christensen A, Funch Uhre C, et al · · 2023 · PMID 37497354 · DOI 10.1016/j.conctc.2023.101173