Who is sponsoring NCT03590496?

NCT03590496 is sponsored by Charite University, Berlin, Germany.

What drugs are being tested in NCT03590496?

Interventions in NCT03590496: Calcium-Propionate 500mg, Placebo.

What condition does NCT03590496 study?

NCT03590496 studies Hypercholesterolemia.

Is NCT03590496 still recruiting?

NCT03590496 is currently completed. Last updated 16 September 2020.

Last reviewed 2020-09-16 · How we verify

NCT03590496: PROPER-LDL

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Safety and Efficacy of Propionate for Reduction of LDL Cholesterol

Completed NA Last updated 16 September 2020

What this trial tests

NA trial testing Calcium-Propionate 500mg in Hypercholesterolemia in 62 participants. Completed in 30 June 2020.

Timeline

25 July 2018

Primary endpoint
30 June 2020

30 June 2020

Quick facts

Lead sponsor	Charite University, Berlin, Germany
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	prevention
Enrollment	62
Start date	25 July 2018
Primary completion	30 June 2020
Estimated completion	30 June 2020
Sites	1 location across Germany

Drugs / interventions tested

Calcium-Propionate 500mg
Placebo

Conditions studied

Hypercholesterolemia — all drugs for Hypercholesterolemia →

Sponsor

Charite University, Berlin, Germany

Who can join

Adults 20 to 70, any sex, with Hypercholesterolemia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The objective of the trial is to evaluate a potential impact of food supplements with the short chain fatty acid propionate on blood LDL cholesterol level.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism.
Haghikia A, Zimmermann F, Schumann P, Jasina A, et al · · 2022 · cited 257× · PMID 34597388 · DOI 10.1093/eurheartj/ehab644
The Gut Microbiota Affects Host Pathophysiology as an Endocrine Organ: A Focus on Cardiovascular Disease.
Busnelli M, Manzini S, Chiesa G. · · 2019 · cited 58× · PMID 31892152 · DOI 10.3390/nu12010079
Harnessing and delivering microbial metabolites as therapeutics via advanced pharmaceutical approaches.
Williams LM, Cao S. · · 2024 · cited 13× · PMID 38367866 · DOI 10.1016/j.pharmthera.2024.108605
Modulation of the Serum Metabolome by the Short-Chain Fatty Acid Propionate: Potential Implications for Its Cholesterol-Lowering Effect.
Roessler J, Zimmermann F, Schumann P, Nageswaran V, et al · · 2024 · cited 4× · PMID 39064811 · DOI 10.3390/nu16142368

Verify or expand the search:

Other recruiting trials for Hypercholesterolemia

Currently open trials in the same condition.

NCT07406191 — WB-EMS Effects on Cardiometabolic Risk Factors · NA · recruiting
NCT07374861 — Multicenter Study on the Evaluation of Adherence, Persistence and Efficacy of Treatment With Bempedoic Acid in Italy · recruiting
NCT07295327 — Effect of Two Food Supplements on Lipid Profile in Patients With Mild Hypercholesterolemia · NA · recruiting
NCT06568601 — Pharmacogenomic Informed Statin Prescribing · NA · recruiting
NCT06423365 — A Tool to Help Patients With Muscle Symptoms After Taking a Statin Medication. · NA · active not recruiting

Other Charite University, Berlin, Germany trials

Trials by the same sponsor.

NCT07486167 — Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congeni · Phase 1, PHASE2 · not yet recruiting
NCT07476729 — International Study for Treatment of Childhood Relapsed Precursor B-Cell ALL 2020 (IntReALL BCP 2020) · Phase 3 · not yet recruiting
NCT07503054 — Ovarian Cancer Screening and AI · NA · not yet recruiting
NCT07529197 — Observational Study on Immunoadsorption (IA) in Patients With Autoantibody-Positive Post-Infectious ME/CFS · recruiting
NCT07388693 — Feasibility of Integrating Olfactory Stimuli Into Virtual Reality Cue Exposure for Patients With Alcohol Dependence · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03590496 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Charite University, Berlin, Germany
Last refreshed: 16 September 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03590496.

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